High doses of biotin in chronic progressive multiple sclerosis: A pilot study.
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zeiler
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Christian
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Marsei
TIMS topics
TIMS topics
[URL="http://www.thisisms.com/forum/biotin-ce ... d1003-f56/"][U]TIMS topics[/U][/URL] over biotine
[URL="http://www.thisisms.com/forum/biotin-ce ... d1003-f56/"][U]TIMS topics[/U][/URL] over biotine
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MiSsty
Dank je Marsel.
Dank je Marsel.
Mooi dat je Tim topics met ons hebt gedeeld. Staat veel interessant nieuws in te lezen,:goed:
Mooi dat je Tim topics met ons hebt gedeeld. Staat veel interessant nieuws in te lezen,:goed:
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MiSsty
AbstractSend to:
Mult Scler Relat Disord. 2015 Mar;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. Epub 2015 Jan 24.
High doses of biotin in chronic progressive multiple sclerosis: a pilot study.
Sedel F1, Papeix C2, Bellanger A3, Touitou V4, Lebrun-Frenay C5, Galanaud D6, Gout O7, Lyon-Caen O2, Tourbah A8.
Author information
Abstract
BACKGROUND:
No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
OBJECTIVES:
The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS.
STUDY DESIGN:
Uncontrolled, non-blinded proof of concept study
METHODS:
23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures.
RESULTS:
In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset.
CONCLUSIONS:
These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going.
Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Biotin; Multiple sclerosis; Optic neuritis; Progressive; Visual evoked potentials
PMID: 25787192 [PubMed - in process] Free full text
Mult Scler Relat Disord. 2015 Mar;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. Epub 2015 Jan 24.
High doses of biotin in chronic progressive multiple sclerosis: a pilot study.
Sedel F1, Papeix C2, Bellanger A3, Touitou V4, Lebrun-Frenay C5, Galanaud D6, Gout O7, Lyon-Caen O2, Tourbah A8.
Author information
Abstract
BACKGROUND:
No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
OBJECTIVES:
The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS.
STUDY DESIGN:
Uncontrolled, non-blinded proof of concept study
METHODS:
23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures.
RESULTS:
In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset.
CONCLUSIONS:
These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going.
Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Biotin; Multiple sclerosis; Optic neuritis; Progressive; Visual evoked potentials
PMID: 25787192 [PubMed - in process] Free full text
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Sebastiaan
[QUOTE=Ellen Hamming;1020085]Ben het met je eens. Ze zetten zich lang niet genoeg in. Ik zie steeds hoopvolle dingen voorbij komen en dan wordt het in eens weer stil.Geen reacties van uit MS-verenigingen:???::???::???:[/QUOTE]
Ik ben helaas niet de enige die weg is. ALLE personeel is weg, wat de continuïteit niet ten goede komt. Ik ben blij dat het team van MSweb wel gewoon doordraait.
Ik ben helaas niet de enige die weg is. ALLE personeel is weg, wat de continuïteit niet ten goede komt. Ik ben blij dat het team van MSweb wel gewoon doordraait.
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Dango
[QUOTE=Marsei;1020114][URL="http://www.thisisms.com/forum/biotin-ce ... d1003-f56/"][U]TIMS topics[/U][/URL] over biotine[/QUOTE]
ff kort door de bocht: Biotine = vitamine B7 ??
ff kort door de bocht: Biotine = vitamine B7 ??
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MiSsty
Gekopieerd van Biotin for progressive MS
Gekopieerd van Biotin for progressive MS
Gekopieerd van Biotin for progressive MS
besloten groep op facebook
Hi everyone,
i work in a pharmacy laboratory in Italy (Farmacia Piazza Villari of Turin).
We have BIOTIN in our lab, and from local hospital we started receiving prescription for capsules of biotin 100 mg for each.
I post here the actual prices, if ever someone could be interested:
Biotin 100 mg 100 capsules: 50,33 €
Biotin 150 mg 100 capsules: 66,83 €
Biotin 300 mg 100 capsules: 116,33 €
I even post the certificate of analysis of Biotin.
Please feel free to ask me anything (or even you can go to farmacia piazza villari page here on fb
ondertekend door Alberto Paggi
MiSsty
Gekopieerd van Biotin for progressive MS
besloten groep op facebook
Hi everyone,
i work in a pharmacy laboratory in Italy (Farmacia Piazza Villari of Turin).
We have BIOTIN in our lab, and from local hospital we started receiving prescription for capsules of biotin 100 mg for each.
I post here the actual prices, if ever someone could be interested:
Biotin 100 mg 100 capsules: 50,33 €
Biotin 150 mg 100 capsules: 66,83 €
Biotin 300 mg 100 capsules: 116,33 €
I even post the certificate of analysis of Biotin.
Please feel free to ask me anything (or even you can go to farmacia piazza villari page here on fb
ondertekend door Alberto Paggi
MiSsty