ECTRIMS 2015
[URL="https://www.youtube.com/watch?v=TI5GeQvpgEc"][U]Video[/U][/URL]: Dr. Daniel Kantor talks about the role of fatty acids in the central nervous system and how it may benefit MS patients.
MS en de relatie met de darmen
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Bixi
[QUOTE=joge;967948][url]http://www.mavenpublishing.nl/boeken/allemaal-beestjes/[/url]
Binnenkort weer een poepboek. Bacteriën worden sexy! En vergeet niet de tweewegverbinding tussen darmen en brein: je Nervus Vagus (mijn stokpaardje...:p).
Is de analyse van je darmmicrobioom genoeg voor een totale blik op je gezondheid? Het lijkt erop dat zo’n analyse minstens zo’n uitgebreide blik op je medische gesteldheid geeft als een analyse van je DNA. Wetenschapsjournalist Jop de Vrieze ging op onderzoek uit, ondervond het aan den lijve en schreef het boek.[/QUOTE]
Hoi,
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?
Binnenkort weer een poepboek. Bacteriën worden sexy! En vergeet niet de tweewegverbinding tussen darmen en brein: je Nervus Vagus (mijn stokpaardje...:p).
Is de analyse van je darmmicrobioom genoeg voor een totale blik op je gezondheid? Het lijkt erop dat zo’n analyse minstens zo’n uitgebreide blik op je medische gesteldheid geeft als een analyse van je DNA. Wetenschapsjournalist Jop de Vrieze ging op onderzoek uit, ondervond het aan den lijve en schreef het boek.[/QUOTE]
Hoi,
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?
-
neuron
Poep transplantatie
Poep transplantatie
[QUOTE=Bixi;1027730]Hoi,
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?[/QUOTE]
Je kunt ook
1 - je voeding aanpassen,
2 - probiotica,
3 - omega 3 en
4 - vitamine D3 gaan slikken.
Een poep transplantatie heeft geen zin als je niet ook 1 tm 4 doet.
.
[QUOTE=Bixi;1027730]Hoi,
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?[/QUOTE]
Je kunt ook
1 - je voeding aanpassen,
2 - probiotica,
3 - omega 3 en
4 - vitamine D3 gaan slikken.
Een poep transplantatie heeft geen zin als je niet ook 1 tm 4 doet.
.
-
Marsei
[QUOTE=Bixi;1027730]Hoi,
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?[/QUOTE]
In ieder geval bij de [URL="http://www.vumc.nl/onderzoek/nieuws/vum ... plantatie/"][U]VU[/U][/URL], maar dan bij een hardnekkige, terugkerende bacteriële infectie.
Kan je zo 'n analize ergens in Nederland laten doen ? Of wordt ergens darmflora- transplantatie uitgevoerd?[/QUOTE]
In ieder geval bij de [URL="http://www.vumc.nl/onderzoek/nieuws/vum ... plantatie/"][U]VU[/U][/URL], maar dan bij een hardnekkige, terugkerende bacteriële infectie.
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Marsei
Gut bacteria seems different in people with MS
Gut bacteria seems different in people with MS
[URL="http://www.msra.org.au/gut-bacteria-see ... -people-ms"][U]Gut bacteria[/U][/URL] seems different in people with MS
[QUOTE]Changes to gut bacteria have been found in some inflammatory conditions and their potential role in MS is an emerging area of research.[/QUOTE]
[QUOTE]A new study from researchers in Japan has looked at the profile of gut bacteria in 20 Japanese people with relapsing remitting MS and compared this with 40 healthy control individuals. Since the bacterial profile can be variable over time, they also included multiple samples from the same group of healthy people that were taken over a number of months.
Published in PLoS One, the study showed that while gut bacteria was broadly similar to healthy people, 21 species did show differences. In particular, the bacteria belonging to the clostridial species were present in differing amounts. This was true of the single time point comparison as well as the samples taken over time, strengthening the results. However, the bacterial species identified are not the same as those that have previously been shown to be involved with autoimmunity and allergy. This suggests that the bacterial profile in MS may be distinct and may represent a potential target for new therapies.
MS Research Australia has funded a similar study led by Dr Stuart Smith at Deakin University in Melbourne looking at differences in microbiota in Australian patients and comparing this with control subjects. Since lifestyle factors have such a large influence on gut microbiota, it will be interesting to compare the results of the Australian study with the Japanese results. The Australian study is currently underway and actively recruiting.[/QUOTE]
[URL="http://www.msra.org.au/gut-bacteria-see ... -people-ms"][U]Gut bacteria[/U][/URL] seems different in people with MS
[QUOTE]Changes to gut bacteria have been found in some inflammatory conditions and their potential role in MS is an emerging area of research.[/QUOTE]
[QUOTE]A new study from researchers in Japan has looked at the profile of gut bacteria in 20 Japanese people with relapsing remitting MS and compared this with 40 healthy control individuals. Since the bacterial profile can be variable over time, they also included multiple samples from the same group of healthy people that were taken over a number of months.
Published in PLoS One, the study showed that while gut bacteria was broadly similar to healthy people, 21 species did show differences. In particular, the bacteria belonging to the clostridial species were present in differing amounts. This was true of the single time point comparison as well as the samples taken over time, strengthening the results. However, the bacterial species identified are not the same as those that have previously been shown to be involved with autoimmunity and allergy. This suggests that the bacterial profile in MS may be distinct and may represent a potential target for new therapies.
MS Research Australia has funded a similar study led by Dr Stuart Smith at Deakin University in Melbourne looking at differences in microbiota in Australian patients and comparing this with control subjects. Since lifestyle factors have such a large influence on gut microbiota, it will be interesting to compare the results of the Australian study with the Japanese results. The Australian study is currently underway and actively recruiting.[/QUOTE]
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Marsei
WHAT DOES YOUR GUT MICROBIOME LOOK LIKE?
WHAT DOES YOUR GUT MICROBIOME LOOK LIKE?
WHAT DOES YOUR [URL="http://www.popsci.com/visualizing-gut-m ... slide-show"][U]GUT MICROBIOME LOOK LIKE[/U][/URL]?
SCIENTISTS CAN NOW SEE HOW DIET IMPACTS THE GUT AND ITS MICROBES—AND YOU CAN, TOO
[QUOTE]The microbes in your gut depend on you to feed them well. A steady diet of complex fibers keeps them happy—and by extension, may keep you healthier. The microbiota have been linked to weight, gut health, allergies and even mood. Studies have shown that when the host (you) fails to supply the hungry hordes of beneficial microbes with what they want, the populations can change, and can even start to threaten the gut's thin lining. But we have been unable to see exactly whether—and how—these shifts were happening.
Now a team at Stanford University has created an elegant method of peering inside the gut—at cell-level resolution—to see what is going on.[/QUOTE]
[QUOTE]Sonnenburg and his colleagues fed mice (colonized with human gut microbes) standard and fiber-deficient diets. They then carefully preserved thin slices of the mouse intestines and added special dyes to mark different microbes, undigested food, the essential mucus layer and the gut wall. With so many minute sample slices to analyze, they also developed software to help compute the spatial relationships.
In being able to actually see what was happening on these different diets, the researchers found that when the fiber was reduced, the mucus layer shrank—likely due to starved microbes eating it—from approximately 51 micrometers to just 31, allowing the microbes closer to the sensitive wall of the intestine. And as Sonnenburg notes, "we know that part of maintaining harmony between our resident microbes and our intestinal tissue is separation of the two"—namely by the mucus layer.
As this mucus layer shrank, mice missing the fiber in their diet also had more markers of inflammation. This can be triggered by the immune system attempting to keep bugs where they belong—in the gut. "Over long periods of time, low levels of inflammation can lead to many different types of problems, including colitis or even cancer," Sonnenburg says. (But, he cautions, the experiments have only been in mice—and over a short time period—so how the findings translate to us and our long-term health remain to be seen.)
In addition to the shrinking mucus layer, the researchers were also able to see that changing the diet altered the way bacteria were organized in the gut. On a standard diet, two categories of bacteria were usually found in clumps of similar cells. But without fiber, these groupings vanished, and the microbes were more evenly distributed.[/QUOTE]
WHAT DOES YOUR [URL="http://www.popsci.com/visualizing-gut-m ... slide-show"][U]GUT MICROBIOME LOOK LIKE[/U][/URL]?
SCIENTISTS CAN NOW SEE HOW DIET IMPACTS THE GUT AND ITS MICROBES—AND YOU CAN, TOO
[QUOTE]The microbes in your gut depend on you to feed them well. A steady diet of complex fibers keeps them happy—and by extension, may keep you healthier. The microbiota have been linked to weight, gut health, allergies and even mood. Studies have shown that when the host (you) fails to supply the hungry hordes of beneficial microbes with what they want, the populations can change, and can even start to threaten the gut's thin lining. But we have been unable to see exactly whether—and how—these shifts were happening.
Now a team at Stanford University has created an elegant method of peering inside the gut—at cell-level resolution—to see what is going on.[/QUOTE]
[QUOTE]Sonnenburg and his colleagues fed mice (colonized with human gut microbes) standard and fiber-deficient diets. They then carefully preserved thin slices of the mouse intestines and added special dyes to mark different microbes, undigested food, the essential mucus layer and the gut wall. With so many minute sample slices to analyze, they also developed software to help compute the spatial relationships.
In being able to actually see what was happening on these different diets, the researchers found that when the fiber was reduced, the mucus layer shrank—likely due to starved microbes eating it—from approximately 51 micrometers to just 31, allowing the microbes closer to the sensitive wall of the intestine. And as Sonnenburg notes, "we know that part of maintaining harmony between our resident microbes and our intestinal tissue is separation of the two"—namely by the mucus layer.
As this mucus layer shrank, mice missing the fiber in their diet also had more markers of inflammation. This can be triggered by the immune system attempting to keep bugs where they belong—in the gut. "Over long periods of time, low levels of inflammation can lead to many different types of problems, including colitis or even cancer," Sonnenburg says. (But, he cautions, the experiments have only been in mice—and over a short time period—so how the findings translate to us and our long-term health remain to be seen.)
In addition to the shrinking mucus layer, the researchers were also able to see that changing the diet altered the way bacteria were organized in the gut. On a standard diet, two categories of bacteria were usually found in clumps of similar cells. But without fiber, these groupings vanished, and the microbes were more evenly distributed.[/QUOTE]
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Leonard
Het artikel van de Japanse researchers in PLOS:
[url]http://journals.plos.org/plosone/articl ... ne.0137429[/url]
[url]http://journals.plos.org/plosone/articl ... ne.0137429[/url]
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neuron
ECTRIMS 2015
ECTRIMS 2015
[QUOTE]Code: P879
Abstract: 1275
The Gut-Brain CD39+ T regulatory cell Axis: role of the microbiota and gut associated lymphoid tissue in regulating inflammatory CNS demyelination
J. Ochoa-Reparaz1, E. Kasper1, C. Kircher1, Y. Wang1, K. Telesford1, S. Haque-Begum1, A. Pant1, L.H. Kasper2
1Dartmouth College, 2Microbiology/Immunology, Dartmouth College, Hanover, NH, United States
Recent evidence shows that the gut microbiota is essential for the normal development and function of the immune system. Germ-free mice cannot develop experimental inflammatory disease such as EAE. Gut microbiome alterations due to both environmental and genetic factors can be associated with experimental autoimmunity, including CNS inflammatory demyelination.
We have investigated the role of gut derived functionally distinct regulatory T cells (Tregs) in response to alteration of the microbiome. Others have shown that circulating CD39+Tregs are reduced in both number and capacity to suppress IL-17 by CD4+ T cells in those with relapsing MS. CD39 is an ecto-enzyme that dephosphorylates ATP to adenosine.
We have reported that the polysaccharide-A (PSA), a symbiont factor produced by the human commensal B. fragilis, protects against murine EAE. Oral treatment with PSA induces IL-10-producing CD39+ FoxP3+Tregs that accumulate in the CNS of EAE mice and functionally suppress the inflammatory response. The increase of CD39+Tregs can persist for months after the last treatment with PSA.
In vitro human studies show PSA can convert and amplify CD39+ expression by naïve human CD4+ T cells. We demonstrate herein that some of the approved oral and infused IMD therapies for relapsing MS promote an enhanced frequency of GALT derived CD39+Tregs.
Teriflunomide (20mg/kg) (Aubagio) when delivered by oral gavage to mice reduces both frequencies and numbers of certain immune compartments in the gut associated lymphoid tissue (GALT e.g. Peyer's patches) whereas there is a concomitant, significant increase in the frequencies of CD39+Tregs among total leukocyte population. Teriflunomide-induced GALT derived Tregs suppress the proliferation of MOG-specific auto-reactive T cells in vitro.
Similarly s.c. administration of murine anti-CD52 in EAE mice promotes a phenotypic rise in GALT derived CD39+Tregs. Of interest, our previously reported preliminary human data suggests that infused anti-CD52 (Lemtrada) enhances a population of circulating CD39+Tregs amongst the residual CD4+ T cells at 4-6 months post infusion.
Our data and those of others evaluating CD39+ Tregs in response to fingolimod lead us to hypothesize that GALT derived CD39+Tregs are a key immunoregulatory factor that IMD therapies promote in the gut, and constitute a common mechanism of action for the protective effects of both oral and infusion based therapies currently approved to treat MS.
[/QUOTE]
.
[QUOTE]Code: P879
Abstract: 1275
The Gut-Brain CD39+ T regulatory cell Axis: role of the microbiota and gut associated lymphoid tissue in regulating inflammatory CNS demyelination
J. Ochoa-Reparaz1, E. Kasper1, C. Kircher1, Y. Wang1, K. Telesford1, S. Haque-Begum1, A. Pant1, L.H. Kasper2
1Dartmouth College, 2Microbiology/Immunology, Dartmouth College, Hanover, NH, United States
Recent evidence shows that the gut microbiota is essential for the normal development and function of the immune system. Germ-free mice cannot develop experimental inflammatory disease such as EAE. Gut microbiome alterations due to both environmental and genetic factors can be associated with experimental autoimmunity, including CNS inflammatory demyelination.
We have investigated the role of gut derived functionally distinct regulatory T cells (Tregs) in response to alteration of the microbiome. Others have shown that circulating CD39+Tregs are reduced in both number and capacity to suppress IL-17 by CD4+ T cells in those with relapsing MS. CD39 is an ecto-enzyme that dephosphorylates ATP to adenosine.
We have reported that the polysaccharide-A (PSA), a symbiont factor produced by the human commensal B. fragilis, protects against murine EAE. Oral treatment with PSA induces IL-10-producing CD39+ FoxP3+Tregs that accumulate in the CNS of EAE mice and functionally suppress the inflammatory response. The increase of CD39+Tregs can persist for months after the last treatment with PSA.
In vitro human studies show PSA can convert and amplify CD39+ expression by naïve human CD4+ T cells. We demonstrate herein that some of the approved oral and infused IMD therapies for relapsing MS promote an enhanced frequency of GALT derived CD39+Tregs.
Teriflunomide (20mg/kg) (Aubagio) when delivered by oral gavage to mice reduces both frequencies and numbers of certain immune compartments in the gut associated lymphoid tissue (GALT e.g. Peyer's patches) whereas there is a concomitant, significant increase in the frequencies of CD39+Tregs among total leukocyte population. Teriflunomide-induced GALT derived Tregs suppress the proliferation of MOG-specific auto-reactive T cells in vitro.
Similarly s.c. administration of murine anti-CD52 in EAE mice promotes a phenotypic rise in GALT derived CD39+Tregs. Of interest, our previously reported preliminary human data suggests that infused anti-CD52 (Lemtrada) enhances a population of circulating CD39+Tregs amongst the residual CD4+ T cells at 4-6 months post infusion.
Our data and those of others evaluating CD39+ Tregs in response to fingolimod lead us to hypothesize that GALT derived CD39+Tregs are a key immunoregulatory factor that IMD therapies promote in the gut, and constitute a common mechanism of action for the protective effects of both oral and infusion based therapies currently approved to treat MS.
[/QUOTE]
.
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vlinder009
Ik was tot mijn 20e bijna nooit ziek, alleen wel vaak moe vanaf dat ik naar de middelbare school ging, maar geen griep of verkoudheid, geen darmklachten e.d.
Toen ik 20 was kreeg ik enorm last van mijn darmen, dit heeft 2 jaar dag en nacht geduurd en inmiddels heb ik ook vanwege mijn darmklachten moeten stoppen met mijn opleiding destijds (ik had aan een stuk door diarree constant).
Daarna kreeg ik ineens MS klachten (uitval) en dus de diagnose gekregen en nu wel weer wat hersteld van de darmklachten, maar mijn neuro blijft volhouden dat de darmklachten niks met de MS te maken heeft :???:
Ik denk dus ook dat er een relatie is met de darmen en MS.
Toen ik 20 was kreeg ik enorm last van mijn darmen, dit heeft 2 jaar dag en nacht geduurd en inmiddels heb ik ook vanwege mijn darmklachten moeten stoppen met mijn opleiding destijds (ik had aan een stuk door diarree constant).
Daarna kreeg ik ineens MS klachten (uitval) en dus de diagnose gekregen en nu wel weer wat hersteld van de darmklachten, maar mijn neuro blijft volhouden dat de darmklachten niks met de MS te maken heeft :???:
Ik denk dus ook dat er een relatie is met de darmen en MS.
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neuron
[QUOTE=vlinder009;1028696]Ik was tot mijn 20e bijna nooit ziek, alleen wel vaak moe vanaf dat ik naar de middelbare school ging, maar geen griep of verkoudheid, geen darmklachten e.d.
Toen ik 20 was kreeg ik enorm last van mijn darmen, dit heeft 2 jaar dag en nacht geduurd en inmiddels heb ik ook vanwege mijn darmklachten moeten stoppen met mijn opleiding destijds (ik had aan een stuk door diarree constant).
Daarna kreeg ik ineens MS klachten (uitval) en dus de diagnose gekregen en nu wel weer wat hersteld van de darmklachten, maar mijn neuro blijft volhouden dat de darmklachten niks met de MS te maken heeft :???:
Ik denk dus ook dat er een relatie is met de darmen en MS.[/QUOTE]
Vlinder009,
Ik denk dat jouw neuro niks met MS te maken heeft!!!
Wat een vreselijk verhaal, wat naar voor je.
Heb je antibiotica gebruikt voordat je darmen in de war gingen?
Gebruik je nu probiotica?
Als je nog steeds last van je darmen hebt moet je misschien eens een afspraak maken met Max Nieuwdorp in het AMC. Of aan hem vragen waar je het best terechtkan met je klachten. Hij is de poep dokter van Nederland, maar richt zich vooral op diabetes.
.
Toen ik 20 was kreeg ik enorm last van mijn darmen, dit heeft 2 jaar dag en nacht geduurd en inmiddels heb ik ook vanwege mijn darmklachten moeten stoppen met mijn opleiding destijds (ik had aan een stuk door diarree constant).
Daarna kreeg ik ineens MS klachten (uitval) en dus de diagnose gekregen en nu wel weer wat hersteld van de darmklachten, maar mijn neuro blijft volhouden dat de darmklachten niks met de MS te maken heeft :???:
Ik denk dus ook dat er een relatie is met de darmen en MS.[/QUOTE]
Vlinder009,
Ik denk dat jouw neuro niks met MS te maken heeft!!!
Wat een vreselijk verhaal, wat naar voor je.
Heb je antibiotica gebruikt voordat je darmen in de war gingen?
Gebruik je nu probiotica?
Als je nog steeds last van je darmen hebt moet je misschien eens een afspraak maken met Max Nieuwdorp in het AMC. Of aan hem vragen waar je het best terechtkan met je klachten. Hij is de poep dokter van Nederland, maar richt zich vooral op diabetes.
.