Witte stof / grijze stof

[Marsei]

[URL="http://www.biomedcentral.com/content/pd ... 11-152.pdf"][U]Cortical injury[/U][/URL] in multiple sclerosis; the role of the immune system

[URL="http://www.bmedreport.com/archives/31937"][U]Persconferentie[/U][/URL]: Multiple Sclerosis Often Starts In Brain’s Outer Layers
[QUOTE]Multiple sclerosis (MS) may progress from the outermost layers of the brain to its deep parts, and is not always an “inside-out” process as previously thought, reported a new collaborative study from researchers at the Mayo Clinic and the Cleveland Clinic. The traditional understanding is that the disease begins in the white matter that forms the bulk of the brain’s inside, and extends to involve the brain’s superficial layers, the cortex. [B]Study findings support an opposite, outside-in process: from the cerebrospinal fluid-filled subarachnoid space, that cushions the outside of the brain and the cortex, into the white matter.[/B][/QUOTE]
[QUOTE]“Our study shows the cortex is involved early in MS and may even be the initial target of disease,” says Claudia F. Lucchinetti, M.D., co-lead author of the study and Mayo Clinic neurologist. “Inflammation in the cortex must be considered when investigating the causes and progression of MS”, she says.[/QUOTE]
[QUOTE]These measures are important because disease accumulates in the cortex over time, and inflammation in the cortex is a sign the disease has progressed.

The research is distinct because it studied brain tissues from patients in the earliest stages of MS. [/QUOTE]
[QUOTE]The findings support the understanding that MS is primarily a disease of inflammation, not neurodegeneration, as some studies have recently suggested. Co-lead authors Drs. Lucchinetti and Ransohoff conclude that it is “overwhelmingly likely” that MS is fundamentally an inflammatory disease, and not a neurodegenerative Alzheimer-like disease.[/QUOTE]
[URL="http://www.youtube.com/watch?feature=pl ... XyMX7kv4jA"][U]Video[/U][/URL]

Joan Beal op [URL="https://www.facebook.com/notes/ccsvi-in ... 4834012211"][U]FB[/U][/URL] over dit onderzoek - New Research from the Mayo Clinic....it's not about White Matter lesions, it's about Gray Matter
[QUOTE]So. Although the researchers don't mention these points in the cheery press release, it might be good to state:

1. White matter lesions are not MS. Therefore, EAE is not MS.

2. We do not know for sure how current disease modulating drugs will affect the cortex.

3. Although the science is not in yet, it is "overwhelmingly likely" that this cortical damage is due to the immune system. Really? Researchers can "weave together" their theory using animal models? Really?

4. How do we account for the high levels of iron deposition in deep gray matter as noted on SWI technology? Venous reflux and stasis, anyone? Iron deposition would most certainly create inflammation in the brain. Perhaps the researchers might want to look at Dr. Haacke and Dr. Zivadinov's research before deciding that it's just aberrant inflammation.
[url]http://www.ajnr.org/content/early/2011/ ... 3.abstract[/url]

I am consistantly amazed at how MS specialists and researchers are able to make the "reassuring" leap that MS is immune modulated, even when everything they thought they knew about the disease turns out to be wrong.[/QUOTE]

[Anne-Marie]

Heel interessante bevindingen!

Bedankt voor het plaatsen!

[peanuts]

[COLOR="Blue"]Thanks Marsei

de bloedaders bereiken vast als eerste de grijze stof ?


[/COLOR]

[QUOTE] MS ziekte van witte en grijze stof

MS werd tot voor kort gezien als een ontstekingsziekte van de witte stof van het centraal zenuwstelsel.
Nu blijkt dat de grijze stof er ook bij betrokken is. De witte stof is de plaats in de hersenen waar de zenuwbanen lopen.

De huidige geneesmiddelen zijn er op gericht om de ontsteking bij MS-patiënten te verminderen.
Nederland telt ruim zestienduizend mensen met MS.

Slechts een deel van hen heeft baat bij de huidige geneesmiddelen.

De laatste jaren is duidelijk geworden dat door de schade in de grijze stof van de hersenen, waar de zenuwcellen liggen, de patiënten steeds verder achteruitgaan. Ze gaan moeilijker lopen en zien en ze kunnen geheugenproblemen krijgen.


[/QUOTE]

[url]http://site.zorgportaal.nl/index.php/zo ... bij-mannen[/url]

[Marsei]

Gray matter atrophy in MS

Nog wat meer info van Joan op [URL="https://www.facebook.com/notes/ccsvi-in ... 6696872211"][U]FB[/U][/URL] over de grijze stof: Gray matter atrophy in MS

[Marsei]

Nature Of Brain Lesions Early In MS Progression, Countering Conventional Wisdom

Biopsies Reveal Nature Of [URL="http://www.medicalnewstoday.com/releases/238870.php"][U]Brain Lesions[/U][/URL] Early In MS Progression, Countering Conventional Wisdom
[QUOTE]However, in autopsy tissues of MS patients, lesions in the cerebral cortex show demyelination without inflammation, raising a challenging issue: if cortical lesions form entirely without inflammation, then cortical demyelination would not be explainable by current theories of MS nor treatable by current MS therapies. [/QUOTE]

[Marsei]

MRI Abnormalities in MS Vary With Distance From Lesions

[URL="http://www.mdnews.com/news/hd/2011_51/h ... 4.facebook"][U]MRI Abnormalities in MS Vary With Distance From Lesions[/U][/URL]
[QUOTE]Magnetic resonance imaging (MRI) abnormalities in normal-appearing white matter (NAWM) in multiple sclerosis (MS) brains vary with the distance from the white matter (WM) lesion, according to a study published online Dec. 7 in the Annals of Neurology.[/QUOTE]

[Marsei]

Gray matter imaging in Multiple Sclerosis: what have we learned?

[URL="http://www.biomedcentral.com/content/pd ... 11-153.pdf"][U]Publicatie[/U][/URL] van de VU: Gray matter imaging in Multiple Sclerosis: what have we learned?

Conclusies Pagina 10

[Marsei]

Dr. Juurlink over laesies

Van [URL="https://www.facebook.com/nationalccsvisociety"][U]FB[/U][/URL]: [QUOTE]Dr. Juurlink gave us his opinion of grey vs. white matter lesions at a meeting of our National CCSVI Society support group in Victoria this week. My paraphrasing would be it's all about blood flow and oxygenation of tissues. Grey matter lesions take longer to develop because there are 3 redundant systems to supply blood and oxygen to the vital grey matter and only one mechanism for the white matter. So the white matter is more vulnerable and shows damage first from reduced blood flow. The longer we have CCSVI, the more likely lesions are going to develop in our grey matter.[/QUOTE]

[Marsei]

UTHealth researchers link multiple sclerosis to different area of brain

[URL="http://www.eurekalert.org/pub_releases/ ... 122211.php"][U]UTHealth researchers [/U][/URL]link multiple sclerosis to different area of brain
[QUOTE]Radiology researchers at The University of Texas Health Science Center at Houston (UTHealth) have found evidence that multiple sclerosis affects an area of the brain that controls cognitive, sensory and motor functioning apart from the disabling damage caused by the disease's visible lesions.[/QUOTE]
[QUOTE]"The thalamus is a central area that relates to the rest of the brain and acts as the 'post office,' " said Hasan, first author of the paper. "It also is an area that has the least amount of damage from lesions in the brain but we see volume loss, so it appears other brain damage related to the disease is also occurring."[/QUOTE]
[QUOTE]"Multiple sclerosis patients have cognitive deficits and the thalamus plays an important role in cognitive function. The lesions we can see but there is subclinical activity in multiple sclerosis where you can't see the changes," said senior author Narayana. "There are neurodegenerative changes even when the brain looks normal and we saw this damage early in the disease process."[/QUOTE]
[QUOTE]Adjusting for age-related changes in the thalamus, the patients with multiple sclerosis had less thalamic volume than the controls. The amount of thalamic loss also appeared to be related to the severity of disability.

"This is looking at multiple sclerosis in a different way," Hasan said. "The thalami are losing cellular content and we can use this as a marker of what's going on. [/QUOTE]
[URL="http://www.natuurinformatie.nl/nnm.doss ... 04328.html"][U]Meer info[/U][/URL] over de thalamus

[Marsei]

Iron and gray matter loss

Van joan Beal op [URL="https://www.facebook.com/notes/ccsvi-in ... 8815267211"][U]FB[/U][/URL]: Iron and gray matter loss- What do we know?
[QUOTE]As more and more MS reseachers come forward and explain how MS appears to be a disease of the gray matter first---before white matter lesions appear---it is vital that we look at gray matter structures in the MS brain, to see what is different in the MS brain when compared to normal brains.

This note will be long....but I believe it's important to understand MS research as it stands today, the beginning of 2012.[/QUOTE]
[QUOTE][B]To summarize[/B]-
Dr. Zamboni and Dr. Zivadinov found a direct correlation between

1. severity of CCSVI--or altered venous hemodynamics--
2. amount of iron deposited into gray matter
3. disability
4. gray matter atrophy
5. disease duration

Again....that is a direct, in vivo correlation between the level of altered venous blood flow, gray matter atrophy, iron deposited into gray matter and MS disability.[/QUOTE]