Brain's Ability To Self-Repair Boosted By Natural [URL="http://www.medicalnewstoday.com/article ... A.facebook"][U]Protein[/U][/URL]
[QUOTE]Researchers from the Medical Research Council (MRC) in the UK have found a protein made by blood vessels in the brain that could be a good candidate for regenerative therapies that stimulate the brain to repair itself after injury or disease. [/QUOTE]
[QUOTE]In this study, the MRC researchers studied the interaction between the cells that line the blood vessels (endothelial cells) and the NSCs, and found that a protein called betacellulin (BTC) boosted brain regeneration in mice by stimulating the NSCs to multiply and form new brain cells.
The researchers found that BTC, which is produced by cells within the blood vessels in the stem cell niches, signals to both the stem cells and to dividing cells called neuroblasts, triggering their proliferation.
When they gave mice more BTC, they noticed a significant increase in both stem cells and neuroblasts, leading to formation of many new neurons in their brains.
But when they gave the mice an antibody that blocks BTC, new neuron production stopped.[/QUOTE]
[QUOTE]Because BTC leads to the production of new neurons rather than glial cells, the researchers hope their findings could help future therapies that aim to regenerate damaged or diseased parts of the brain, such as following stroke, traumatic brain injury, and possibly even in the case of dementia.
[/QUOTE]
Ontwikkelingen mbt herstel
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Marsei
Study finds age-related effects in MS may be reversible
Study finds age-related effects in MS may be reversible
Study finds age-related effects in [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1845"][U]MS[/U][/URL] may be reversible
[QUOTE]Scientists at Joslin Diabetes Center, Harvard University, and the University of Cambridge have found that the age-related impairment of the body’s ability to replace protective myelin sheaths, which normally surround nerve fibers and allow them to send signals properly, may be reversible, offering new hope that therapeutic strategies aimed at restoring efficient regeneration can be effective in the central nervous system throughout life.[/QUOTE]
Study finds age-related effects in [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1845"][U]MS[/U][/URL] may be reversible
[QUOTE]Scientists at Joslin Diabetes Center, Harvard University, and the University of Cambridge have found that the age-related impairment of the body’s ability to replace protective myelin sheaths, which normally surround nerve fibers and allow them to send signals properly, may be reversible, offering new hope that therapeutic strategies aimed at restoring efficient regeneration can be effective in the central nervous system throughout life.[/QUOTE]
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Marsei
MS cognitive research yields myelin repair surprise
MS cognitive research yields myelin repair surprise
MS cognitive research yields [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1845"][U]myelin repair[/U][/URL] surprise
[QUOTE]In his own studies, Pickering was looking at links between damage to myelin and cognition, or the ability of the brain to function in learning. And while working with a type of drug that can enhance cognition, he discovered that it also had a welcome talent for prompting the repair of damaged myelin in cells growing in the lab.
“The project wasn’t initially to look at the myelin itself, it was to look at cognition, a secondary effect of the loss of myelin,” he recalls. “But we found that treatment with this drug accelerated the repair of myelin.”
The work, which was funded by the MS Society of Ireland, used neurons or nerve cells growing in a dish.
Pickering treated the neurons with a toxin that damages the myelin surrounding the neurons, and then he looked at the effects of adding this cognition-enhancing drug.
Neurons without the added drug repaired the myelin slowly over several days, but if the drug was added the myelin repair was dramatically faster, says fellow researcher Dr Keith Murphy, a principle investigator at the neurotherapeutics research group in UCD.
“At 24 hours after the toxin was removed, the myelin around the neurons is still very depleted in the normal situation, whereas if you had added the cognition-enhancing drug the myelin is completely normal at that point,” he explains.
“The amount of myelin left after the toxin alone would be 20 per cent of healthy levels, but with the drug on board it is back up to normal.” The cognition-enhancing drug also appears to accelerate myelin repair in other pre-clinical models where myelin has been damaged, according to the researchers.[/QUOTE]
MS cognitive research yields [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1845"][U]myelin repair[/U][/URL] surprise
[QUOTE]In his own studies, Pickering was looking at links between damage to myelin and cognition, or the ability of the brain to function in learning. And while working with a type of drug that can enhance cognition, he discovered that it also had a welcome talent for prompting the repair of damaged myelin in cells growing in the lab.
“The project wasn’t initially to look at the myelin itself, it was to look at cognition, a secondary effect of the loss of myelin,” he recalls. “But we found that treatment with this drug accelerated the repair of myelin.”
The work, which was funded by the MS Society of Ireland, used neurons or nerve cells growing in a dish.
Pickering treated the neurons with a toxin that damages the myelin surrounding the neurons, and then he looked at the effects of adding this cognition-enhancing drug.
Neurons without the added drug repaired the myelin slowly over several days, but if the drug was added the myelin repair was dramatically faster, says fellow researcher Dr Keith Murphy, a principle investigator at the neurotherapeutics research group in UCD.
“At 24 hours after the toxin was removed, the myelin around the neurons is still very depleted in the normal situation, whereas if you had added the cognition-enhancing drug the myelin is completely normal at that point,” he explains.
“The amount of myelin left after the toxin alone would be 20 per cent of healthy levels, but with the drug on board it is back up to normal.” The cognition-enhancing drug also appears to accelerate myelin repair in other pre-clinical models where myelin has been damaged, according to the researchers.[/QUOTE]
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Marsei
Omega-3 fatty acids could prevent and treat nerve damage
Omega-3 fatty acids could prevent and treat nerve damage
Omega-3 fatty acids could prevent and treat [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/2479"][U]nerve damage[/U][/URL]
[QUOTE]The new study, published this week in the Journal of Neuroscience, suggests that omega-3 fatty acids could play a significant role in speeding recovery from nerve injury.[/QUOTE]
[QUOTE]In the new study, researchers first looked at isolated mouse nerve cells. They simulated the type of damage caused by accident or injury, by either stretching the cells or starving them of oxygen. Both types of damage killed a significant number of nerve cells but enrichment with omega-3 fatty acids in cells gave them significant protection and decreased cell death.
Next the researchers studied the sciatic nerves of mice. They found that a high level of omega-3 fatty acids helped mice to recover from sciatic nerve injury more quickly and more fully, and that their muscles were less likely to waste following nerve damage.[/QUOTE]
Omega-3 fatty acids could prevent and treat [URL="http://www.msrc.co.uk/index.cfm/fuseact ... ageid/2479"][U]nerve damage[/U][/URL]
[QUOTE]The new study, published this week in the Journal of Neuroscience, suggests that omega-3 fatty acids could play a significant role in speeding recovery from nerve injury.[/QUOTE]
[QUOTE]In the new study, researchers first looked at isolated mouse nerve cells. They simulated the type of damage caused by accident or injury, by either stretching the cells or starving them of oxygen. Both types of damage killed a significant number of nerve cells but enrichment with omega-3 fatty acids in cells gave them significant protection and decreased cell death.
Next the researchers studied the sciatic nerves of mice. They found that a high level of omega-3 fatty acids helped mice to recover from sciatic nerve injury more quickly and more fully, and that their muscles were less likely to waste following nerve damage.[/QUOTE]
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Marsei
MS damage washed away by stream of young blood
MS damage washed away by stream of young blood
[URL="http://www.newscientist.com/article/mg2 ... blood.html"][U]MS damage[/U][/URL] washed away by stream of young blood
[QUOTE]New myelin-generating cells can be produced from stem cells, but the process loses efficiency with age.
Julia Ruckh at the University of Cambridge, and colleagues, have found a way to reverse the age-related efficiency loss. They linked the bloodstreams of young mice to old mice with myelin damage. Exposure to youthful blood reactivated stem cells in the old mice, boosting myelin generation.
White blood cells called macrophages from the young mice gathered at the sites of myelin damage. Macrophages engulf and destroy pathogens and debris, including destroyed myelin (Cell Stem Cell, DOI: 10.1016/j.stem.2011.11.019)
"We know this debris inhibits regeneration, so clearing it up is important," says team member Amy Wagers of Harvard University.
Neil Scolding at the University of Bristol, UK, who was not involved in the new work, says reactivating ageing stem cells may be a more realistic approach for treating MS than transplanting stem cells from a donor.[/QUOTE]
[URL="http://www.focushms.com/features/age-re ... eversible/"][U]Age-related effects of MS may prove reversible[/U][/URL]
[URL="http://www.newscientist.com/article/mg2 ... blood.html"][U]MS damage[/U][/URL] washed away by stream of young blood
[QUOTE]New myelin-generating cells can be produced from stem cells, but the process loses efficiency with age.
Julia Ruckh at the University of Cambridge, and colleagues, have found a way to reverse the age-related efficiency loss. They linked the bloodstreams of young mice to old mice with myelin damage. Exposure to youthful blood reactivated stem cells in the old mice, boosting myelin generation.
White blood cells called macrophages from the young mice gathered at the sites of myelin damage. Macrophages engulf and destroy pathogens and debris, including destroyed myelin (Cell Stem Cell, DOI: 10.1016/j.stem.2011.11.019)
"We know this debris inhibits regeneration, so clearing it up is important," says team member Amy Wagers of Harvard University.
Neil Scolding at the University of Bristol, UK, who was not involved in the new work, says reactivating ageing stem cells may be a more realistic approach for treating MS than transplanting stem cells from a donor.[/QUOTE]
[URL="http://www.focushms.com/features/age-re ... eversible/"][U]Age-related effects of MS may prove reversible[/U][/URL]
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Luit
Marsei,
Ik vind dit toch zo raar...
Je opent een topic en schrijft er zelf niks in!
Misschien dat anderen er wat aan hebben maar voor mij zijn dit non-topics.
En ja, hoor, ik kan wel Engels lezen en begrijpen.
Maar ik kan ook surfen op internet en indien nodig deze info vinden.
IK begrijp dat er soms dit soort van ondersteuning in een topic dient toegevoegd te worden.
Maar het wordt steeds erger: je plaatst nu nog enkel citaten en dan nog enkel in het Engels.
Nogmaals: hopelijk voor anderen maar mij doen of zeggen ze niks.
Wat is je bedoeling hiermee?
Ik vind dit toch zo raar...
Je opent een topic en schrijft er zelf niks in!
Misschien dat anderen er wat aan hebben maar voor mij zijn dit non-topics.
En ja, hoor, ik kan wel Engels lezen en begrijpen.
Maar ik kan ook surfen op internet en indien nodig deze info vinden.
IK begrijp dat er soms dit soort van ondersteuning in een topic dient toegevoegd te worden.
Maar het wordt steeds erger: je plaatst nu nog enkel citaten en dan nog enkel in het Engels.
Nogmaals: hopelijk voor anderen maar mij doen of zeggen ze niks.
Wat is je bedoeling hiermee?
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Vlinder70
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de echte willem
onze Marsei struint dag en nacht het www af op zoek naar zaken die ons zouden kunnen helpen
ik heb daar veel respect voor en zie altijd met belangstelling uit naar nieuwe vondsten
gaan er een paar de boel afzeiken
wat een forum
heb er maar 1 woord voor
BAHHHHHHHHHHHHHHHHHH
ik ben weer een poosje weg
word er misselijk van
wat een ondankbaarheid
Gatver
ik heb daar veel respect voor en zie altijd met belangstelling uit naar nieuwe vondsten
gaan er een paar de boel afzeiken
wat een forum
heb er maar 1 woord voor
BAHHHHHHHHHHHHHHHHHH
ik ben weer een poosje weg
word er misselijk van
wat een ondankbaarheid
Gatver