Kankermedicijn voor beschadigde neuronen
[URL="http://www.msweb.nl/nieuws/4803"][U]Van MS-web[/U][/URL]: Kankermedicijn voor beschadigde neuronen
[QUOTE]Het kankermedicijn Epothilone is in staat, mits in lage dosis toegediend, beschadigde neuronen weer te laten aangroeien. Tevens beperkt het littekenvorming. Dit maakt het middel mogelijk geschikt voor behandeling van MS.[/QUOTE]
Ontwikkelingen mbt herstel
-
Marsei
Spinal cord tissue provides clues
Spinal cord tissue provides clues
[URL="http://www.msra.org.au/spinal-cord-tiss ... ides-clues"][U]Spinal cord tissue[/U][/URL] provides clues
[QUOTE]A recent study from Italian researchers at the University of Milan has found that certain molecules were present in significantly lower levels in the spinal cords of people with MS. The researchers suggest that this may play a role in the failure of myelin repair that causes the accumulation of damage in MS.[/QUOTE]
[QUOTE]Using specialised molecular biology techniques, the researchers studied the levels of three specific molecules – cobalamin, epidermal growth factor (EGF), and cellular prions. These molecules are known to be involved in the process of myelin production, and all work together to regulate the environment around the nerve in order to promote and encourage the growth of functional myelin around each nerve cell.
The researchers set out to identify whether the levels of these molecules were different in the spinal cords of people who had MS, compared to the control group. They found that each of these three molecules was decreased in MS within the spinal cord tissue compared to the control group, and were also altered in the cerebrospinal fluid that surrounds the brain and spinal cord.
Because cobalamin, EGF, and cellular prions have been shown to play a role in the production of myelin, the researchers suggest that reduced levels of these molecules may be part of the road-block preventing myelin repair in MS. Further research will help to determine whether new treatments could be developed to target these molecules, to remove this road-block and allow new myelin to be produced and reverse MS-related damage.[/QUOTE]
[URL="http://www.msra.org.au/spinal-cord-tiss ... ides-clues"][U]Spinal cord tissue[/U][/URL] provides clues
[QUOTE]A recent study from Italian researchers at the University of Milan has found that certain molecules were present in significantly lower levels in the spinal cords of people with MS. The researchers suggest that this may play a role in the failure of myelin repair that causes the accumulation of damage in MS.[/QUOTE]
[QUOTE]Using specialised molecular biology techniques, the researchers studied the levels of three specific molecules – cobalamin, epidermal growth factor (EGF), and cellular prions. These molecules are known to be involved in the process of myelin production, and all work together to regulate the environment around the nerve in order to promote and encourage the growth of functional myelin around each nerve cell.
The researchers set out to identify whether the levels of these molecules were different in the spinal cords of people who had MS, compared to the control group. They found that each of these three molecules was decreased in MS within the spinal cord tissue compared to the control group, and were also altered in the cerebrospinal fluid that surrounds the brain and spinal cord.
Because cobalamin, EGF, and cellular prions have been shown to play a role in the production of myelin, the researchers suggest that reduced levels of these molecules may be part of the road-block preventing myelin repair in MS. Further research will help to determine whether new treatments could be developed to target these molecules, to remove this road-block and allow new myelin to be produced and reverse MS-related damage.[/QUOTE]
-
Marsei
New MS Therapy Seen to Promote Myelin Regeneration
New MS Therapy Seen to Promote Myelin Regeneration
New MS Therapy Seen to [URL="http://multiplesclerosisnewstoday.com/2 ... cal-study/"][U]Promote Myelin Regeneration[/U][/URL] in Preclinical Study
[QUOTE]Researchers from the Departments of Neurology and Biostatistics and Research Epidemiology, Henry Ford Health System in Detroit, and from the Department of Physics at Oakland University in Rochester, both in Michigan, showed that Tβ4 is an effective remyelination therapy, able to promote proliferation and differentiation of OPCs into mature, myelin-producing oligodendrocytes, while also decreasing axonal damage. The research team also observed that the epidermal growth factor receptor (EGFR) signaling pathway contributes to this process.
Two different animal models extensively used in MS research, the experimental autoimmune encephalomyelitis (EAE) model and the cuprizone diet model, were used to evaluate this potential mechanism of CNS repair. In both, the improved rate of remyelination and mature oligodendrocytes generation significantly correlated with functional improvement in the mice.[/QUOTE]
New MS Therapy Seen to [URL="http://multiplesclerosisnewstoday.com/2 ... cal-study/"][U]Promote Myelin Regeneration[/U][/URL] in Preclinical Study
[QUOTE]Researchers from the Departments of Neurology and Biostatistics and Research Epidemiology, Henry Ford Health System in Detroit, and from the Department of Physics at Oakland University in Rochester, both in Michigan, showed that Tβ4 is an effective remyelination therapy, able to promote proliferation and differentiation of OPCs into mature, myelin-producing oligodendrocytes, while also decreasing axonal damage. The research team also observed that the epidermal growth factor receptor (EGFR) signaling pathway contributes to this process.
Two different animal models extensively used in MS research, the experimental autoimmune encephalomyelitis (EAE) model and the cuprizone diet model, were used to evaluate this potential mechanism of CNS repair. In both, the improved rate of remyelination and mature oligodendrocytes generation significantly correlated with functional improvement in the mice.[/QUOTE]
-
Marsei
Neurogenese
Neurogenese
[URL="https://www.youtube.com/embed/B_tjKYvEziI"][U]Video[/U][/URL]: You Can Grow New Brain Cells. Here's How | Sandrine Thuret | TED Talks
[URL="https://www.youtube.com/embed/B_tjKYvEziI"][U]Video[/U][/URL]: You Can Grow New Brain Cells. Here's How | Sandrine Thuret | TED Talks
-
Marsei
Which Type of Exercise Is Best for the Brain?
Which Type of Exercise Is Best for the Brain?
Which [URL="http://well.blogs.nytimes.com/2016/02/1 ... EMARK&_r=3"][U]Type of Exercise[/U][/URL] Is Best for the Brain?
[QUOTE]Some forms of exercise may be much more effective than others at bulking up the brain, according to a remarkable new study in rats. For the first time, scientists compared head-to-head the neurological impacts of different types of exercise: running, weight training and high-intensity interval training. The surprising results suggest that going hard may not be the best option for long-term brain health.
As I have often written, exercise changes the structure and function of the brain. Studies in animals and people have shown that physical activity generally increases brain volume and can reduce the number and size of age-related holes in the brain’s white and gray matter.[/QUOTE]
[QUOTE]They found very different levels of neurogenesis, depending on how each animal had exercised.
Those rats that had jogged on wheels showed robust levels of neurogenesis. Their hippocampal tissue teemed with new neurons, far more than in the brains of the sedentary animals. The greater the distance that a runner had covered during the experiment, the more new cells its brain now contained.
There were far fewer new neurons in the brains of the animals that had completed high-intensity interval training. They showed somewhat higher amounts than in the sedentary animals but far less than in the distance runners.
And the weight-training rats, although they were much stronger at the end of the experiment than they had been at the start, showed no discernible augmentation of neurogenesis. Their hippocampal tissue looked just like that of the animals that had not exercised at all.
Obviously, rats are not people. But the implications of these findings are provocative. They suggest, said Miriam Nokia, a research fellow at the University of Jyvaskyla who led the study, that “sustained aerobic exercise might be most beneficial for brain health also in humans.”
Just why distance running was so much more potent at promoting neurogenesis than the other workouts is not clear, although Dr. Nokia and her colleagues speculate that distance running stimulates the release of a particular substance in the brain known as brain-derived neurotrophic factor that is known to regulate neurogenesis. The more miles an animal runs, the more B.D.N.F. it produces.
Weight training, on the other hand, while extremely beneficial for muscular health, has previously been shown to have little effect on the body’s levels of B.D.N.F., Dr. Nokia said, which could explain why it did not contribute to increased neurogenesis in this study.
As for high-intensity interval training, its potential brain benefits may be undercut by its very intensity, Dr. Nokia said. It is, by intent, much more physiologically draining and stressful than moderate running, and “stress tends to decrease adult hippocampal neurogenesis,” she said.
These results do not mean, however, that only running and similar moderate endurance workouts strengthen the brain, Dr. Nokia said. Those activities do seem to prompt the most neurogenesis in the hippocampus. But weight training and high-intensity intervals probably lead to different types of changes elsewhere in the brain. They might, for instance, encourage the creation of additional blood vessels or new connections between brain cells or between different parts of the brain.
So if you currently weight train or exclusively work out with intense intervals, continue. But perhaps also thread in an occasional run or bike ride for the sake of your hippocampal health.
[/QUOTE]
Which [URL="http://well.blogs.nytimes.com/2016/02/1 ... EMARK&_r=3"][U]Type of Exercise[/U][/URL] Is Best for the Brain?
[QUOTE]Some forms of exercise may be much more effective than others at bulking up the brain, according to a remarkable new study in rats. For the first time, scientists compared head-to-head the neurological impacts of different types of exercise: running, weight training and high-intensity interval training. The surprising results suggest that going hard may not be the best option for long-term brain health.
As I have often written, exercise changes the structure and function of the brain. Studies in animals and people have shown that physical activity generally increases brain volume and can reduce the number and size of age-related holes in the brain’s white and gray matter.[/QUOTE]
[QUOTE]They found very different levels of neurogenesis, depending on how each animal had exercised.
Those rats that had jogged on wheels showed robust levels of neurogenesis. Their hippocampal tissue teemed with new neurons, far more than in the brains of the sedentary animals. The greater the distance that a runner had covered during the experiment, the more new cells its brain now contained.
There were far fewer new neurons in the brains of the animals that had completed high-intensity interval training. They showed somewhat higher amounts than in the sedentary animals but far less than in the distance runners.
And the weight-training rats, although they were much stronger at the end of the experiment than they had been at the start, showed no discernible augmentation of neurogenesis. Their hippocampal tissue looked just like that of the animals that had not exercised at all.
Obviously, rats are not people. But the implications of these findings are provocative. They suggest, said Miriam Nokia, a research fellow at the University of Jyvaskyla who led the study, that “sustained aerobic exercise might be most beneficial for brain health also in humans.”
Just why distance running was so much more potent at promoting neurogenesis than the other workouts is not clear, although Dr. Nokia and her colleagues speculate that distance running stimulates the release of a particular substance in the brain known as brain-derived neurotrophic factor that is known to regulate neurogenesis. The more miles an animal runs, the more B.D.N.F. it produces.
Weight training, on the other hand, while extremely beneficial for muscular health, has previously been shown to have little effect on the body’s levels of B.D.N.F., Dr. Nokia said, which could explain why it did not contribute to increased neurogenesis in this study.
As for high-intensity interval training, its potential brain benefits may be undercut by its very intensity, Dr. Nokia said. It is, by intent, much more physiologically draining and stressful than moderate running, and “stress tends to decrease adult hippocampal neurogenesis,” she said.
These results do not mean, however, that only running and similar moderate endurance workouts strengthen the brain, Dr. Nokia said. Those activities do seem to prompt the most neurogenesis in the hippocampus. But weight training and high-intensity intervals probably lead to different types of changes elsewhere in the brain. They might, for instance, encourage the creation of additional blood vessels or new connections between brain cells or between different parts of the brain.
So if you currently weight train or exclusively work out with intense intervals, continue. But perhaps also thread in an occasional run or bike ride for the sake of your hippocampal health.
[/QUOTE]
-
Marsei
Brain rewires itself after damage or injury
Brain rewires itself after damage or injury
[URL="https://www.sciencedaily.com/releases/2 ... rain+News)"][U]Brain rewires itself[/U][/URL] after damage or injury, life scientists discover
[QUOTE]The brain forms complex new circuits after damage to compensate for lost function, often far from the damaged region, life scientists report.
The new study identified the exact regions of the brain that take over when the brain's hippocampus is damaged, and is the first demonstration of such neural circuit plasticity.[/QUOTE]
[URL="https://www.sciencedaily.com/releases/2 ... rain+News)"][U]Brain rewires itself[/U][/URL] after damage or injury, life scientists discover
[QUOTE]The brain forms complex new circuits after damage to compensate for lost function, often far from the damaged region, life scientists report.
The new study identified the exact regions of the brain that take over when the brain's hippocampus is damaged, and is the first demonstration of such neural circuit plasticity.[/QUOTE]
-
Marsei
Spinal Cord Implant
Spinal Cord Implant
[URL="https://www.facebook.com/ScienceNatureP ... 075740319/"][U]Video[/U][/URL]: Spinal Cord Implant
[URL="https://www.facebook.com/ScienceNatureP ... 075740319/"][U]Video[/U][/URL]: Spinal Cord Implant