Manipulatie van de data in het COSMO onderzoek
Van Joan op [URL="https://www.facebook.com/notes/ccsvi-in ... 6647652211"][U]FB[/U][/URL]: The Truth about the COSMO study - Manipulatie van de data in het COSMO onderzoek, hét onderzoek dat definitief had moeten bewijzen dat CCSVI flauwekul is.
[QUOTE]How can a study claim to be presenting true statistics, when 90% of the positive findings are thrown out? That's correct. [B]90% of the positive findings of CCSVI in people with MS in the Italian COSMO study were thrown out by the head of the study.[/B] Here is Dr. Zamboni on this fact:
Asked for comment on the findings, Dr. Zamboni confirmed that he was not happy with the COSMO study design.
"Our seminal paper published in 2009 in JNNP compared Doppler sonography with catheter venography, and found 90% and 75% abnormalities respectively in the jugular and in the azygous veins of MS patients," he told Medscape Medical News. "COSMO trial was initially aimed to verify my data in a wide sample and in a multicenter setting."
"Unfortunately," he said, the study compared Doppler sonography with the agreement of 3 central readers. "This design is not [as] solid of course as comparing ultrasound with venography," Dr. Zamboni added. Moreover, 90% of CCSVI cases discovered in peripheral centers were over-ruled by the central readers, and classified as false positive.
"To me, this study mainly confirms the absence of reproducibility of Doppler sonography in the absence of good CCSVI training, and further suggests to assess patients via [multimodal] diagnostic techniques."
[url]http://www.medscape.com/viewarticle/773381[/url]
Dr. Michael Dake refers to this in his presentation at ISET last weekend---
There was local blinding of the sonographic readings---but the "central investigators" got the final say. That's right, they could overturn the sonographers findings of CCSVI. And that's exactly what they did.
90% of the CCSVI cases diagnosed by local sonographers were overturned by central investigator interpretations.
page 68 from [url]http://www.eventscribe.com/2013/ISETCIO ... /52589.pdf[/url]
The three central readers who overturned these positive CCSVI findings stated they over-ruled the findings because the local sonographers might have been biased by seeing people with MS.
Stolz attributed the lack of concordance on positive findings to the fact that "local sonographers are not on the moon." He suggested that seeing participants, and noting any physical or mental impairments, could have biased them toward diagnosing CCSVI.[/QUOTE]
[QUOTE][B]This is not science.[/B] This is manipulating medicine to maintain control of a disease aetiology. And it is wrong.
For more on the conflicts of interest in the COSMO CCSVI study:
[url]https://www.facebook.com/notes/ccsvi-in ... 6960927211[/url]
Here is the abstract for the COSMO study, which the authors proudly claim has finally "put an end to CCSVI."
[url]http://registration.akm.ch/einsicht.php ... KEN_ID=900[/url]
Ironically, the text for authors' pharmaceutical disclosures is as long as the text for the abstract.[/QUOTE]
CCSVI - 9
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Marsei
ISET 2013
ISET 2013
ISET 2013
[QUOTE]Session IV: New Interventional Treatments for Disease Management
Multiple Sclerosis and the Venous System: Is there a Link?
Michael Dake, MD
Stanford University School of Medicine, Stanford, CA
calendar1/19/2013
clock1:30 PM - 2:00 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52589.pdf[/url]
Session IV
CCSVI: Is it Real and What do We Know?
Michael Dake, MD
Stanford University School of Medicine, Stanford, CA
calendar1/20/2013
clock3:30 PM - 3:45 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52593.pdf[/url]
Session IV
Techniques and Outcomes of Venous Interventions for CCSVI
Gary Siskin, MD
Professor and Chairman, Department of Radiology; Chief of Vascular and Interventional Radiology, Albany Medical Center, Albany, New York, Albany Medical College, Albany, NY
calendar1/20/2013
clock3:45 PM - 4:00 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52868.pdf[/url][/QUOTE]
Lees bij Siskin de outcomes, de to-do list en de conclusie.
ISET 2013
[QUOTE]Session IV: New Interventional Treatments for Disease Management
Multiple Sclerosis and the Venous System: Is there a Link?
Michael Dake, MD
Stanford University School of Medicine, Stanford, CA
calendar1/19/2013
clock1:30 PM - 2:00 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52589.pdf[/url]
Session IV
CCSVI: Is it Real and What do We Know?
Michael Dake, MD
Stanford University School of Medicine, Stanford, CA
calendar1/20/2013
clock3:30 PM - 3:45 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52593.pdf[/url]
Session IV
Techniques and Outcomes of Venous Interventions for CCSVI
Gary Siskin, MD
Professor and Chairman, Department of Radiology; Chief of Vascular and Interventional Radiology, Albany Medical Center, Albany, New York, Albany Medical College, Albany, NY
calendar1/20/2013
clock3:45 PM - 4:00 PM
[url]http://www.eventscribe.com/2013/ISETCIO ... /52868.pdf[/url][/QUOTE]
Lees bij Siskin de outcomes, de to-do list en de conclusie.
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Robbie
De waarheid over de Cosmo studie
De waarheid over de Cosmo studie
Excuses moi
[url]http://sphotos-g.ak.fbcdn.net/hphotos-a ... 0328_n.jpg[/url]
Excuses moi
[url]http://sphotos-g.ak.fbcdn.net/hphotos-a ... 0328_n.jpg[/url]
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Robbie
Buffalo trial (uit de haacke pdf)
Buffalo trial (uit de haacke pdf)
Op pag 68 staat dat de Promise resultaten bekend zijn en binnenkort gepubliceerd worden.
Op pag 68 staat dat de Promise resultaten bekend zijn en binnenkort gepubliceerd worden.
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Marsei
Italiaanse conferentie op 9 februari
Italiaanse conferentie op 9 februari
[URL="http://www.ccsvi-lombardia.org/?p=1570"][U]CCSVI in MS[/U][/URL] conferentie op 9 februari in Lombardije
[URL="http://www.ccsvi-lombardia.org/?p=1570"][U]CCSVI in MS[/U][/URL] conferentie op 9 februari in Lombardije
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Marsei
Ventriculomegaly and Mega Cisterns in Alzheimer’s, Parkinsons and MS
Ventriculomegaly and Mega Cisterns in Alzheimer’s, Parkinsons and MS
the [URL="http://uprightdoctor.wordpress.com/2012 ... ns-and-ms/"][U]Uprightdoctor[/U][/URL]: Ventriculomegaly and Mega Cisterns in Alzheimer’s, Parkinsons and MS
[QUOTE]The ventricles are chambers in the center of the brain and brainstem where a watery substance called cerebrospinal fluid (CSF) is produced. The purpose of CSF is to support and protect the brain. It also removes waste from the brain. Enlargement of the ventricles is called ventriculomegaly. Ventriculomegaly seen on brain scans is a sign of hydrocephalus, which is an increase in CSF volume in the brain.
Ventriculomegaly stretches and deforms the surrounding periventricular structures. Prolonged deformation can lead to plastic deformation, which is permanent. Ventriculomegaly also compresses the veins, that are located on the outer surface of the brain, against the bones of the cranial vault. This can decrease venous drainage of the brain and cause the hydrocephalic condition to worsen. Ventriculomegaly and damage to periventricular structures may play a role in many of the signs and symptoms associated with neurodegenerative diseases such as motor weaknesses, dementia, cog fog, heat intolerance, sleep disturbances, sleep apnea and incontinence of the bowel and bladder.[/QUOTE]
[QUOTE]Since the advent of brain scans, ventriculomegaly has been associated with Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and other neurodegenerative conditions. [/QUOTE]
[QUOTE]Ventriculomegaly can be caused by an increase in CSF volume and pressure in the ventricles, or it can be caused by atrophy (shrinking) of the brain due to degeneration of the structures that surround them. It can also be a combination of atrophy and changes in CSF volume and pressure. In many cases the cause of the ventriculomegaly is unknown. In any case, enlargement of the ventricles can affect the important structures that surround them in what is called the periventricular areas.
[/QUOTE]
[QUOTE]Similarly, poroelasticity affects the structural strength and shape of the brain, as well as deformation such as ventriculomegaly. This is important because deformation of the brain such as enlarged ventricles can damage nearby delicate nerves and blood vessels. Damage to nerves and blood vessels can, in turn, lead to atrophy (shrinkage) and ventriculomegaly.[/QUOTE]
[QUOTE]Hydraulic force is a product of pressure multiplied by the size of the area the pressure is being applied to, such as the volume of the ventricles or cisterns for example. A hydraulic pump can be used to increase force by applying pressure to a larger cylinder. Similarly, the pressure from the heart exerts more force on the larger pores and spaces of the brain compared to smaller ones. In this regard, the largest spaces in the brain are the ventricles and cisterns. The effects of hydraulic force may play a role in the ventriculomegaly seen in neurodegenerative condtions such as Alzheimer’s, Parkinson’s and multiple sclerosis. Constant strain from increased force in the ventricles and cisterns may cause a breakdown in the elastic properties of the brain so that the ventricles and surrounding structures can no longer return to their original shape, which is called plastic (permanent) deformation. [/QUOTE]
the [URL="http://uprightdoctor.wordpress.com/2012 ... ns-and-ms/"][U]Uprightdoctor[/U][/URL]: Ventriculomegaly and Mega Cisterns in Alzheimer’s, Parkinsons and MS
[QUOTE]The ventricles are chambers in the center of the brain and brainstem where a watery substance called cerebrospinal fluid (CSF) is produced. The purpose of CSF is to support and protect the brain. It also removes waste from the brain. Enlargement of the ventricles is called ventriculomegaly. Ventriculomegaly seen on brain scans is a sign of hydrocephalus, which is an increase in CSF volume in the brain.
Ventriculomegaly stretches and deforms the surrounding periventricular structures. Prolonged deformation can lead to plastic deformation, which is permanent. Ventriculomegaly also compresses the veins, that are located on the outer surface of the brain, against the bones of the cranial vault. This can decrease venous drainage of the brain and cause the hydrocephalic condition to worsen. Ventriculomegaly and damage to periventricular structures may play a role in many of the signs and symptoms associated with neurodegenerative diseases such as motor weaknesses, dementia, cog fog, heat intolerance, sleep disturbances, sleep apnea and incontinence of the bowel and bladder.[/QUOTE]
[QUOTE]Since the advent of brain scans, ventriculomegaly has been associated with Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and other neurodegenerative conditions. [/QUOTE]
[QUOTE]Ventriculomegaly can be caused by an increase in CSF volume and pressure in the ventricles, or it can be caused by atrophy (shrinking) of the brain due to degeneration of the structures that surround them. It can also be a combination of atrophy and changes in CSF volume and pressure. In many cases the cause of the ventriculomegaly is unknown. In any case, enlargement of the ventricles can affect the important structures that surround them in what is called the periventricular areas.
[/QUOTE]
[QUOTE]Similarly, poroelasticity affects the structural strength and shape of the brain, as well as deformation such as ventriculomegaly. This is important because deformation of the brain such as enlarged ventricles can damage nearby delicate nerves and blood vessels. Damage to nerves and blood vessels can, in turn, lead to atrophy (shrinkage) and ventriculomegaly.[/QUOTE]
[QUOTE]Hydraulic force is a product of pressure multiplied by the size of the area the pressure is being applied to, such as the volume of the ventricles or cisterns for example. A hydraulic pump can be used to increase force by applying pressure to a larger cylinder. Similarly, the pressure from the heart exerts more force on the larger pores and spaces of the brain compared to smaller ones. In this regard, the largest spaces in the brain are the ventricles and cisterns. The effects of hydraulic force may play a role in the ventriculomegaly seen in neurodegenerative condtions such as Alzheimer’s, Parkinson’s and multiple sclerosis. Constant strain from increased force in the ventricles and cisterns may cause a breakdown in the elastic properties of the brain so that the ventricles and surrounding structures can no longer return to their original shape, which is called plastic (permanent) deformation. [/QUOTE]
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TvG
Alternatief dierenmodel
Alternatief dierenmodel
[URL="http://www.ncbi.nlm.nih.gov/pubmed/23348984"][U]Pubmed: MR imaging of the yucatan pig head and neck vasculature[/U][/URL]
[URL="http://www.ncbi.nlm.nih.gov/pubmed/23348984"][U]Pubmed: MR imaging of the yucatan pig head and neck vasculature[/U][/URL]
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Marsei
CCSVI Weekly News Digest
CCSVI Weekly News Digest
[URL="http://paper.li/CCSVI_Society/130648418 ... =paper_sub"][U] CCSVI Weekly News Digest[/U][/URL]
[URL="http://paper.li/CCSVI_Society/130648418 ... =paper_sub"][U] CCSVI Weekly News Digest[/U][/URL]
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Robbie
SIR 2013
SIR 2013
Tijdens de volgende SIR zal een workshopgehouden worden; 'Neurointerventions II; CCSVI'
Gecoordineerd door Dr Sclafani en Dr Arslan
[quote]
[URL="http://www.msweb.nl/forum/"]Print[/URL] |[URL="http://www.msweb.nl/forum/"]Close[/URL]
[B]Neurointerventions II: Chronic Cerebrospinal Venous Insufficiency (CCSVI) [/B]
Sun, 4/14: 8:00 AM - 9:30 AM
0121
Workshop
WK 21
Ernest N. Morial Convention Center
Room: 396
[B]CME Credits:[/B] 1.5
This workshop will use a case-based interactive format to expose participants to Chronic Cerebrospinal Venous Insufficiency. CCSVI is a clinical syndrome resulting from outflow resistance of the veins that drain the brain and the spine, presenting clinically with chronic fatigue, short term memory loss, problems of concentration and complex thinking, headaches, spasticity and vision deficiencies and treated with some success by venoplasty and valvuloplasty. The workshop speakers will describe clinical presentations, explain their pre-procedural evaluations and preparations and elaborate on the criteria they use to decide which patients might benefit from the procedure. Each presenter will illustrate and explain the techniques that they use to image and treat obstructions and define the end points of their treatments. Finally they will discuss follow-up schema. The types of cases discussed will include the following: Routine uncomplicated cases that illustrate the key components of each speaker's techniques; cases that reveal nuances in technique of each speaker; misdiagnoses, technical errors and complications; "re-do" and "bailout" procedures.
[B]Objective[/B]
Upon completion of the session, the learner should be able to:
1.Describe the pathology and pathophysiology, and clinical presentation of CCSVI
2. Describe the various screening, diagnostic and surveillance approaches to CCSVI
3. Recognize the venographic appearances of CCSVI and formulate a strategy for their detection
4. Develop a coherent and effective treatment strategy
5. Recognize, reduce and treat complications of treatment
[B]Coordinator[/B]
[I]Salvatore Sclafani, MD, FSIR[/I], SUNY Health Science At Brooklyn -
[B]Presentation Speaker(s)[/B]
[I]Bulent Arslan, MD[/I], Rush University Medical Center - [URL="http://www.msweb.nl/forum/"][/URL]
[I]Michael Cumming, MD, FRCP(C), MBA[/I], CDI Vascular -
[I]Hector Ferral, MD[/I], NorthShore University HealthSystem - [URL="http://www.msweb.nl/forum/"][/URL] [/quote]
Tijdens de volgende SIR zal een workshopgehouden worden; 'Neurointerventions II; CCSVI'
Gecoordineerd door Dr Sclafani en Dr Arslan
[quote]
[URL="http://www.msweb.nl/forum/"]Print[/URL] |[URL="http://www.msweb.nl/forum/"]Close[/URL]
[B]Neurointerventions II: Chronic Cerebrospinal Venous Insufficiency (CCSVI) [/B]
Sun, 4/14: 8:00 AM - 9:30 AM
0121
Workshop
WK 21
Ernest N. Morial Convention Center
Room: 396
[B]CME Credits:[/B] 1.5
This workshop will use a case-based interactive format to expose participants to Chronic Cerebrospinal Venous Insufficiency. CCSVI is a clinical syndrome resulting from outflow resistance of the veins that drain the brain and the spine, presenting clinically with chronic fatigue, short term memory loss, problems of concentration and complex thinking, headaches, spasticity and vision deficiencies and treated with some success by venoplasty and valvuloplasty. The workshop speakers will describe clinical presentations, explain their pre-procedural evaluations and preparations and elaborate on the criteria they use to decide which patients might benefit from the procedure. Each presenter will illustrate and explain the techniques that they use to image and treat obstructions and define the end points of their treatments. Finally they will discuss follow-up schema. The types of cases discussed will include the following: Routine uncomplicated cases that illustrate the key components of each speaker's techniques; cases that reveal nuances in technique of each speaker; misdiagnoses, technical errors and complications; "re-do" and "bailout" procedures.
[B]Objective[/B]
Upon completion of the session, the learner should be able to:
1.Describe the pathology and pathophysiology, and clinical presentation of CCSVI
2. Describe the various screening, diagnostic and surveillance approaches to CCSVI
3. Recognize the venographic appearances of CCSVI and formulate a strategy for their detection
4. Develop a coherent and effective treatment strategy
5. Recognize, reduce and treat complications of treatment
[B]Coordinator[/B]
[I]Salvatore Sclafani, MD, FSIR[/I], SUNY Health Science At Brooklyn -
[B]Presentation Speaker(s)[/B]
[I]Bulent Arslan, MD[/I], Rush University Medical Center - [URL="http://www.msweb.nl/forum/"][/URL]
[I]Michael Cumming, MD, FRCP(C), MBA[/I], CDI Vascular -
[I]Hector Ferral, MD[/I], NorthShore University HealthSystem - [URL="http://www.msweb.nl/forum/"][/URL] [/quote]