CCSVI - 9
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Marsei
Venous hemodynamics in neurological disorders
Venous hemodynamics in neurological disorders
[URL="http://www.biomedcentral.com/1741-7015/11/142"][U]Venous hemodynamics in neurological disorders[/U][/URL]: an analytical review with hydrodynamic analysis - Clive B Beggs
[QUOTE]Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular.
CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mechanisms must be at work, which increase the hydraulic resistance of the cerebral vascular bed in MS. Similarly, hydrodynamic changes appear to be responsible for reduced CBF in leukoaraiosis. The hydrodynamic properties of the periventricular veins make these vessels particularly vulnerable to ischemia and plaque formation.
Venous hypertension in the dural sinuses can alter intracranial compliance. Consequently, venous hypertension may change the CSF dynamics, affecting the intracranial windkessel mechanism. MS and NPH appear to share some similar characteristics, with both conditions exhibiting increased CSF pulsatility in the aqueduct of Sylvius.
[B]CCSVI appears to be a real phenomenon associated with MS, which causes venous hypertension in the dural sinuses. However, the role of CCSVI in the pathophysiology of MS remains unclear.[/B][/QUOTE]
[URL="http://www.biomedcentral.com/1741-7015/11/142"][U]Venous hemodynamics in neurological disorders[/U][/URL]: an analytical review with hydrodynamic analysis - Clive B Beggs
[QUOTE]Venous abnormalities contribute to the pathophysiology of several neurological conditions. This paper reviews the literature regarding venous abnormalities in multiple sclerosis (MS), leukoaraiosis, and normal-pressure hydrocephalus (NPH). The review is supplemented with hydrodynamic analysis to assess the effects on cerebrospinal fluid (CSF) dynamics and cerebral blood flow (CBF) of venous hypertension in general, and chronic cerebrospinal venous insufficiency (CCSVI) in particular.
CCSVI-like venous anomalies seem unlikely to account for reduced CBF in patients with MS, thus other mechanisms must be at work, which increase the hydraulic resistance of the cerebral vascular bed in MS. Similarly, hydrodynamic changes appear to be responsible for reduced CBF in leukoaraiosis. The hydrodynamic properties of the periventricular veins make these vessels particularly vulnerable to ischemia and plaque formation.
Venous hypertension in the dural sinuses can alter intracranial compliance. Consequently, venous hypertension may change the CSF dynamics, affecting the intracranial windkessel mechanism. MS and NPH appear to share some similar characteristics, with both conditions exhibiting increased CSF pulsatility in the aqueduct of Sylvius.
[B]CCSVI appears to be a real phenomenon associated with MS, which causes venous hypertension in the dural sinuses. However, the role of CCSVI in the pathophysiology of MS remains unclear.[/B][/QUOTE]
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Marsei
Concomitant analysis of arterial, venous, and CSF flows using phase-contrast MRI
Concomitant analysis of arterial, venous, and CSF flows using phase-contrast MRI
[URL="http://www.nature.com/jcbfm/journal/vao ... 1395a.html"][U]Concomitant analysis of arterial, venous, and CSF flows using phase-contrast MRI[/U][/URL]: a quantitative comparison between MS patients and healthy controls
[QUOTE]We compared PC-MRI measurements of CSF, arterial and venous flows in MS patients to those from a normative cohort of healthy controls (HC). Nineteen MS patients underwent a standardized MR protocol for cerebral examination on a 3T system including Fast cine PC-MRI sequences with peripheral gating in four acquisition planes.
Quantitative data were processed using a homemade software to extract CSF and blood flow regions of interest, animate flows, and calculate cervical and intracranial vascular flow curves during the cardiac cycle (CC). Results were compared with values obtained in 21 HC using multivariate analysis.
Venous flow patterns were comparable in both groups without signs of reflux. Arterial flows (P=0.02) and cervical CSF dynamic oscillations (P=0.01) were decreased in MS patients. No significant differences in venous cerebral and cervical outflows were observed between groups, thereby contradicting the recently proposed theory of venous insufficiency. Unexpected decrease in arterial perfusion in MS patients warrants further correlation to volumetric measurements of the brain.[/QUOTE]
[URL="http://www.nature.com/jcbfm/journal/vao ... 1395a.html"][U]Concomitant analysis of arterial, venous, and CSF flows using phase-contrast MRI[/U][/URL]: a quantitative comparison between MS patients and healthy controls
[QUOTE]We compared PC-MRI measurements of CSF, arterial and venous flows in MS patients to those from a normative cohort of healthy controls (HC). Nineteen MS patients underwent a standardized MR protocol for cerebral examination on a 3T system including Fast cine PC-MRI sequences with peripheral gating in four acquisition planes.
Quantitative data were processed using a homemade software to extract CSF and blood flow regions of interest, animate flows, and calculate cervical and intracranial vascular flow curves during the cardiac cycle (CC). Results were compared with values obtained in 21 HC using multivariate analysis.
Venous flow patterns were comparable in both groups without signs of reflux. Arterial flows (P=0.02) and cervical CSF dynamic oscillations (P=0.01) were decreased in MS patients. No significant differences in venous cerebral and cervical outflows were observed between groups, thereby contradicting the recently proposed theory of venous insufficiency. Unexpected decrease in arterial perfusion in MS patients warrants further correlation to volumetric measurements of the brain.[/QUOTE]
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Leonard
[QUOTE=Marsei;918450][URL="http://www.biomedcentral.com/1741-7015/11/142"][U]Venous hemodynamics in neurological disorders[/U][/URL]: an analytical review with hydrodynamic analysis - Clive B Beggs[/QUOTE]
dank Marsei, ik vind je postings erg waardevol.
wat een prachtig artikel is dit!
dit artikel is gerelateerd:
[url]http://www.sciencedirect.com/science/ar ... 4813000059[/url]
dank Marsei, ik vind je postings erg waardevol.
wat een prachtig artikel is dit!
dit artikel is gerelateerd:
[url]http://www.sciencedirect.com/science/ar ... 4813000059[/url]
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Jolande
[QUOTE=Marsei;918452][URL="http://www.nature.com/jcbfm/journal/vao ... 1395a.html"][U]Concomitant analysis of arterial, venous, and CSF flows using phase-contrast MRI[/U][/URL]: a quantitative comparison between MS patients and healthy controls[/QUOTE]
Mijn sinus overdruk was enorm hoog voor mijn ingreep toen dat werd opgelost loste al mijn 'ms' symptomen op, binnenkort weer een mri :)
Mijn sinus overdruk was enorm hoog voor mijn ingreep toen dat werd opgelost loste al mijn 'ms' symptomen op, binnenkort weer een mri :)
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Leonard
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jackieline
sinus overdruk?
sinus overdruk?
sinus overdruk van welke sinus?...er zijn er meerdere!
sinus overdruk van welke sinus?...er zijn er meerdere!
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Marsei
The Glymphatic System
The Glymphatic System
[URL="http://www.youtube.com/watch?v=ci5NMscK ... e=youtu.be"][U]Video[/U][/URL]: The Glymphatic System
[URL="http://www.youtube.com/watch?v=ci5NMscK ... e=youtu.be"][U]Video[/U][/URL]: The Glymphatic System
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Jolande
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Robbie