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Proteïnen

Alles omtrent voeding en supplementen
Marsei

Proteïnen

Bericht door Marsei »

Range of [URL="http://www.bbc.co.uk/news/health-17952797"][U]brain diseases[/U][/URL] could be treated by single drug
[QUOTE]The tantalising prospect of treating a range of brain diseases, such as Alzheimer's and Parkinson's, all with the same drug, has been raised by UK researchers.

In a study, published in Nature, they prevented brain cells dying in mice with prion disease.

It is hoped the same method for preventing brain cell death could apply in other diseases.

The findings are at an early stage, but have been heralded as "fascinating".
[/QUOTE]
eve

Bericht door eve »

Ik las het vanochtend ook al ergens, erg interessant. ik kwam zojuist ook dit tegen, gaat ook over proteïne, ik weet niet zeker of het al is langsgekomen:

[url]http://mssociety.org.au/documents/news/ ... elease.pdf[/url]

[QUOTE]
So the research team, headed by Dr Steven Petratos, has shown that a modified version of a specific protein is present within active MS lesions in a laboratory model of MS. This modified protein then interacts with
another protein to cause nerve fibre damage. When the scientists blocked either the modification or the interaction between the two proteins, disease progression was halted.[/QUOTE]
Marsei

Bericht door Marsei »

Ik denk dat het hetzelfde onderzoek is als in [URL="http://www.standaard.be/artikel/detail. ... 120507_011"][U]dit artikel[/U][/URL]; in het Nederlands.
Giechel

Bericht door Giechel »

mensen zijn geen muizen maar van zulke berichten zit ik ineens op het puntje van mn stoel.
Marsei

Eiwitnetwerken bij MS

Bericht door Marsei »

Eiwitnetwerken bij MS

Van [URL="http://www.msweb.nl/preklinisch/3831"][U]MS-web[/U][/URL]: Eiwitnetwerken bij MS
[QUOTE]Zo ontdekten de wetenschappers 75 unieke eiwitten van 92 plaatsen die in samenstelling en hoeveelheid statistisch aantoonbaar verschilden tussen de groepen. Met behulp van een bestaand computerprogramma waarin je naar netwerken tussen eiwitten kunt zoeken bleek dat 70 procent van de gevonden eiwitten direct samenhangen met zenuwziektes.

Een netwerk kent zogeheten regeleiwitten. Twee regeleiwitten bleken 64% van de geïdentificeerde eiwitten te reguleren. Het gaat daarbij om een regelaar van zenuwprikkels en om een eiwit dat van belang is voor het produceren van de stoffen die voor de prikkelgeleiding moeten zorgen. Het kunstmatig blokkeren van deze laatste regelaar liet een verandering zien in de afbraak van myeline. [/QUOTE]
Marsei

New Drug Could Treat Alzheimer's, Multiple Sclerosis and Brain Injury

Bericht door Marsei »

New Drug Could Treat Alzheimer's, Multiple Sclerosis and Brain Injury

[URL="http://www.sciencedaily.com/releases/20 ... 171302.htm"][U]New Drug[/U][/URL] Could Treat Alzheimer's, Multiple Sclerosis and Brain Injury
[QUOTE]A new class of drug developed at Northwestern University Feinberg School of Medicine shows early promise of being a one-size-fits-all therapy for Alzheimer's disease, Parkinson's disease, multiple sclerosis and traumatic brain injury by reducing inflammation in the brain.[/QUOTE]
[QUOTE]MW151 and MW189 work by preventing the damaging overproduction of brain proteins called proinflammatory cytokines. Scientists now believe overproduction of these proteins contributes to the development of many degenerative neurological diseases as well as to the neurological damage caused by traumatic brain injury and stroke.
When too many of the cytokines are produced, the synapses of the brain begin to misfire. Eventually the entire organization of the brain falls into disarray, like a computer failing. The neurons lose their connections with each other and can eventually die. The resulting damage in the cortex and hippocampus can compromise memory and decision-making.[/QUOTE]
[QUOTE]In M.S., overproduction of the proinflammatory cytokines damage the central nervous system and the brain. The proteins directly or indirectly destroy the insulation or coverings of the nerve cells that transmit signals down the spinal cord. When the insulation is stripped, messages aren't properly conducted down the spinal cord.
When mice that were induced to develop an M.S.-like disease received MW151 orally, they did not develop disease as severe.
"We inhibited the development of the disease," said William Karpus, the Marie A. Fleming Research Professor of Pathology at the Feinberg School. "Now we need to learn if the drug can prevent relapses of M.S." That study is ongoing in mice and the results will determine whether a patient trial will be planned.
The only current oral drug treatment for M.S. acts at the level of the lymph nodes, Karpus said. Because the brain is the site of the inflammation and damage, a drug that works in the brain is an ideal therapy.[/QUOTE]
Marsei

Possible Trigger for Multiple Sclerosis Nerve Damage

Bericht door Marsei »

Possible Trigger for Multiple Sclerosis Nerve Damage

[URL="http://www.sciencedaily.com/releases/20 ... 154215.htm"][U]Possible Trigger[/U][/URL] for Multiple Sclerosis Nerve Damage
[QUOTE]High-resolution real-time images show in mice how nerves may be damaged during the earliest stages of multiple sclerosis. The results suggest that the critical step happens when fibrinogen, a blood-clotting protein, leaks into the central nervous system and activates immune cells called microglia.[/QUOTE]
[QUOTE]Microglia are cells traditionally thought to control immunity in the nervous system. Previous studies suggested that leakage of fibrinogen activates microglia. In this study, Dr. Akassoglou and her colleagues used a cutting-edge imaging technique called two-photon laser scanning microscopy to watch what happens in an animal model of MS.

"Our results provide the first evidence linking leakage of fibrinogen to neuronal damage," said Dr. Akassoglou, "Vascular changes are the instigator of neurotoxicity."

Using a mouse model of MS, the researchers found that leakage of fibrinogen and microglial activation occurred days before nerve damage began, suggesting they occur in an early, pre-clinical stage of the disease.
During this period, microglia changed shapes and clustered around blood vessels along with other immune cells. Further experiments suggested that fibrinogen activated microglia by binding to a receptor, called CD11b/CD18, which caused the microglia to release reactive oxygen molecules that, in turn, damaged neurons. Inhibiting the binding of fibrinogen to the receptor prevented microglial activation and nerve damage.[/QUOTE]
Marsei

New research: VASCULAR changes initiate neurotoxicity and inflammation in MS

Bericht door Marsei »

New research: VASCULAR changes initiate neurotoxicity and inflammation in MS

Joan op [URL="https://www.facebook.com/notes/ccsvi-in ... 1527422211"][U]FB[/U][/URL] over dit onderzoek: New research: VASCULAR changes initiate neurotoxicity and inflammation in MS

[QUOTE]Fibrinogen is a protein which is made in our livers. It's the sigaling protein for fibrin, which allows our blood to clot. When people develop venous ulcers on their legs, due to chronic venous insufficiency, it's fibrinogen that leaks from the veins and creates a build up of fibrin, depleting the tissue of oxygen and allowing those hallmark ulcers to form. This is called a "fibrin cuff." It's fibrinogen which initiates the coagulation cascade and causes our blood to thicken, as a response to low oxygen levels.

Dr. Zamboni was the first to suggest that MS lesions looked alot like venous ulcers because of the fibrin cuffs found in both sites of injury. And researchers have noted that fibin deposition comes FIRST, before demylination.[/QUOTE]
[QUOTE]Today, there is new research showing the connection between fibrinogen and inflammation in the brain. And it appears Dr. Zamboni's theory on venous congestion and fibrin cuffs may very well be correct.[/QUOTE]
Marsei

Research opens up possibility of therapies to restore blood-brain barrier

Bericht door Marsei »

Research opens up possibility of therapies to restore blood-brain barrier

Research opens up possibility of therapies to [URL="http://m.medicalxpress.com/news/2013-01 ... rrier.html"][U]restore blood-brain barrier[/U][/URL]

Zie voor meer info [URL="http://www.msweb.nl/forum/showpost.php? ... stcount=12"][U]dit bericht[/U][/URL]
Marsei

Fibrinogeen

Bericht door Marsei »

Fibrinogeen

Van [URL="http://www.msweb.nl/preklinisch/4021"][U]MS-web[/U][/URL]: Ontstekingen muizen-MS verder ontrafeld
[QUOTE]In dit artikel laten de onderzoekers zien dat de zenuwschade bij EAE begint met een clustering van zogenaamde microglia, afweercellen in het centraal zenuwstelsel, ten gevolge van een lek in de bloed-hersenbarrière bij de bloedvaten. De clustering van de microglia treedt op onder invloed van fibrinogeen, een stollingseiwit uit het bloed. Onder invloed van het fibrinogeen produceren de geclusterde microglia reactieve zuurstofverbindingen die schadelijk zijn voor de zenuwcellen.

Bij het chemisch of genetisch kunstmatig blokkeren van de fibrinogeenwerking klonterden de microglia niet meer en er ontstond geen zenuwschade meer.
[/QUOTE]
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