Embry zegt dit over het gluten onderzoek:
[QUOTE]The paper can be found on Pubmed. Use EAE and gluten for search and it is the Di Marco paper. There is a link to the full paper on the abstract page. Ignore the abstract but look at figure 2 which clearly shows gluten-free rats doing much better at 40 days out.[/QUOTE]
Ik neem aan dat het [URL="https://www.ncbi.nlm.nih.gov/pubmed/15601316"][U]dit onderzoek[/U][/URL] is.
Als ik meer weet over de zuivel onderzoeken laat ik het weten.
Meer onderzoeken zijn op de [URL="http://www.direct-ms.org/journalarticles.html"][U]site van Direct-MS[/U][/URL] te vinden. Ik weet niet of het up to date is.
Voeding en supplementen
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Marsei
Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis
Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis
Contribution of [URL="https://www.ncbi.nlm.nih.gov/pubmed/28993476"][U]dietary intake[/U][/URL] to relapse rate in early paediatric multiple sclerosis
[QUOTE][B]Abstract[/B]
[B]OBJECTIVE:[/B]
The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers.
[B]METHODS:[/B]
This is a multicentre study done at 11 paediatric MS centres in the USA. Patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) with disease onset before 18 years of age and duration of less than 4 years were included in this study.
Dietary intake during the week before enrolment was assessed with the validated Block Kids Food Screener. The outcome of the study was time from enrolment to the next relapse. 219 patients with paediatric RRMS or CIS were enrolled.
Each 10% increase in energy intake from fat increased the hazard of relapse by 56% (adjusted HR 1.56, 95% CI 1.05 to 2.31, p=0.027), and in particular each 10% increase in saturated fat tripled this hazard (adjusted HR: 3.37, 95% CI 1.34 to 8.43, p=0.009).
In contrast, each additional one cup equivalent of vegetable decreased the hazard of relapse by 50% (adjusted HR: 0.50, 95% CI 0.27 to 0.91, p=0.024).
These associations remained with mutual adjustment and persisted when adjusting for baseline 25(OH) vitamin D serum level. Other studied nutrients were not associated with relapse.
[B]CONCLUSIONS:[/B]
This study suggests that in children with MS, high energy intake from fat, especially saturated fat, may increase the hazard to relapse, while vegetable intake may be independently protective.[/QUOTE]
Van Ashton:
[QUOTE]I was pleased to see the results of a recent study that looked at the relationship between dietary intake and relapse rate in children with MS. [B]Not surprisingly, they found that each 10% increase in saturated fat tripled relapse rate. Also it was found that each additional cup of vegetables decreased the relapse rate by 50%.[/B] Always good to see two of our 22 year-old, nutritional recommendations receiving even more scientific support. [/QUOTE]
Contribution of [URL="https://www.ncbi.nlm.nih.gov/pubmed/28993476"][U]dietary intake[/U][/URL] to relapse rate in early paediatric multiple sclerosis
[QUOTE][B]Abstract[/B]
[B]OBJECTIVE:[/B]
The role of diet in multiple sclerosis (MS) course remains largely unknown. Children with MS have a higher relapse rate compared with MS in adults. Thus, studying the effect of diet on relapse rate in this age group is likely to provide more robust answers.
[B]METHODS:[/B]
This is a multicentre study done at 11 paediatric MS centres in the USA. Patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) with disease onset before 18 years of age and duration of less than 4 years were included in this study.
Dietary intake during the week before enrolment was assessed with the validated Block Kids Food Screener. The outcome of the study was time from enrolment to the next relapse. 219 patients with paediatric RRMS or CIS were enrolled.
Each 10% increase in energy intake from fat increased the hazard of relapse by 56% (adjusted HR 1.56, 95% CI 1.05 to 2.31, p=0.027), and in particular each 10% increase in saturated fat tripled this hazard (adjusted HR: 3.37, 95% CI 1.34 to 8.43, p=0.009).
In contrast, each additional one cup equivalent of vegetable decreased the hazard of relapse by 50% (adjusted HR: 0.50, 95% CI 0.27 to 0.91, p=0.024).
These associations remained with mutual adjustment and persisted when adjusting for baseline 25(OH) vitamin D serum level. Other studied nutrients were not associated with relapse.
[B]CONCLUSIONS:[/B]
This study suggests that in children with MS, high energy intake from fat, especially saturated fat, may increase the hazard to relapse, while vegetable intake may be independently protective.[/QUOTE]
Van Ashton:
[QUOTE]I was pleased to see the results of a recent study that looked at the relationship between dietary intake and relapse rate in children with MS. [B]Not surprisingly, they found that each 10% increase in saturated fat tripled relapse rate. Also it was found that each additional cup of vegetables decreased the relapse rate by 50%.[/B] Always good to see two of our 22 year-old, nutritional recommendations receiving even more scientific support. [/QUOTE]
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Marsei
From Scared School Boy with MS to Doctor of Nutrition
From Scared School Boy with MS to Doctor of Nutrition
From Scared School Boy with MS to [URL="http://nutritionstudies.org/scared-scho ... nutrition/"][U]Doctor of Nutrition[/U][/URL]
From Scared School Boy with MS to [URL="http://nutritionstudies.org/scared-scho ... nutrition/"][U]Doctor of Nutrition[/U][/URL]
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Marsei
Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome
Immunological and Clinical Effect of Diet Modulation of the Gut Microbiome
Immunological and Clinical [URL="https://www.frontiersin.org/articles/10 ... 01391/full"][U]Effect of Diet Modulation of the Gut Microbiome[/U][/URL] in Multiple Sclerosis Patients: A Pilot Study
[QUOTE]Pathogenesis of autoimmune disorders, including multiple sclerosis (MS), has been linked to an alteration of the resident microbial commensal community and of the interplay between the microbiota and the immune system. Dietary components such as fiber, acting on microbiota composition, could, in principle, result in immune modulation and, thus, could be used to obtain beneficial outcomes for patients.
We verified this hypothesis in a pilot study involving two groups of clinically similar relapsing-remitting (RR) MS patients who had undergone either a high-vegetable/low-protein diet (HV/LP diet group; N = 10) or a “Western Diet” (WD group; N = 10) for at least 12 months.
Gut microbiota composition, analyzed by 16 S V4 rRNA gene sequencing and immunological profiles, was examined after a minimum of 12 months of diet.
Results showed that, in the HV/LP diet group compared to the WD group: (1) Lachnospiraceae family was significantly more abundant; (2) IL-17-producing T CD4+ lymphocytes (p = 0.04) and PD-1 expressing T CD4+ lymphocytes (p = 0.0004) were significantly decreased; and (3) PD-L1 expressing monocytes (p = 0.009) were significantly increased. In the HV/LP diet group, positive correlations between Lachnospiraceae and both CD14+/IL-10+ and CD14+/TGFβ+monocytes (RSp = 0.707, p = 0.05, and RSp = 0.73, p = 0.04, respectively), as well as between Lachnospiraceae and CD4+/CD25+/FoxP3+ T lymphocytes (RSp = 0.68, p = 0.02) were observed.
[B]Evaluation of clinical parameters showed that in the HV/LP diet group alone the relapse rate during the 12 months follow-up period and the Expanded Disability Status Scale score at the end of the study period were significantly reduced.[/B]
Diet modulates dysbiosis and improves clinical parameters in MS patients by increasing anti-inflammatory circuits. Because Lachnospiraceae favor Treg differentiation as well as TGFβ and IL-10 production this effect could be associated with an increase of these bacteria in the microbiota.[/QUOTE]
Immunological and Clinical [URL="https://www.frontiersin.org/articles/10 ... 01391/full"][U]Effect of Diet Modulation of the Gut Microbiome[/U][/URL] in Multiple Sclerosis Patients: A Pilot Study
[QUOTE]Pathogenesis of autoimmune disorders, including multiple sclerosis (MS), has been linked to an alteration of the resident microbial commensal community and of the interplay between the microbiota and the immune system. Dietary components such as fiber, acting on microbiota composition, could, in principle, result in immune modulation and, thus, could be used to obtain beneficial outcomes for patients.
We verified this hypothesis in a pilot study involving two groups of clinically similar relapsing-remitting (RR) MS patients who had undergone either a high-vegetable/low-protein diet (HV/LP diet group; N = 10) or a “Western Diet” (WD group; N = 10) for at least 12 months.
Gut microbiota composition, analyzed by 16 S V4 rRNA gene sequencing and immunological profiles, was examined after a minimum of 12 months of diet.
Results showed that, in the HV/LP diet group compared to the WD group: (1) Lachnospiraceae family was significantly more abundant; (2) IL-17-producing T CD4+ lymphocytes (p = 0.04) and PD-1 expressing T CD4+ lymphocytes (p = 0.0004) were significantly decreased; and (3) PD-L1 expressing monocytes (p = 0.009) were significantly increased. In the HV/LP diet group, positive correlations between Lachnospiraceae and both CD14+/IL-10+ and CD14+/TGFβ+monocytes (RSp = 0.707, p = 0.05, and RSp = 0.73, p = 0.04, respectively), as well as between Lachnospiraceae and CD4+/CD25+/FoxP3+ T lymphocytes (RSp = 0.68, p = 0.02) were observed.
[B]Evaluation of clinical parameters showed that in the HV/LP diet group alone the relapse rate during the 12 months follow-up period and the Expanded Disability Status Scale score at the end of the study period were significantly reduced.[/B]
Diet modulates dysbiosis and improves clinical parameters in MS patients by increasing anti-inflammatory circuits. Because Lachnospiraceae favor Treg differentiation as well as TGFβ and IL-10 production this effect could be associated with an increase of these bacteria in the microbiota.[/QUOTE]
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Marsei
Fats and oils impact disability in MS patients
Fats and oils impact disability in MS patients
[URL="http://www.ms-uk.org/fats-and-oils-impa ... ts-ectrims"][U]Fats and oils[/U][/URL] impact disability in MS patients #ECTRIMS
[QUOTE]A study has shown a significant correlation between the intake of saturated fatty acids and disability and fatigue in MS patients.
The study consisted of 126 patients diagnosed with MS (84 RRMS, 21 PPMS and 21 SPMS) who were recruited with MRI assessment of the brain and spinal cord from an MS clinic in Kashani Hospital of Isfahan University of Medical Sciences, in Iran.
All participants were assessed using a 168-item semi-quantitive food frequency questionnaire to assess dietary intakes of fatty acids, a medical history questionnaire, the expanded disability status scale (EDSS) and a fatigue questionnaire.
The average EDSS and fatigue scale in the SPMS and PPMS groups was significantly higher than the RRMS group. There was a significant correlation between intakes of polyunsaturated fatty acids (PUFAs) including linolenic acid and linoleic acid with EDSS in all participants. In addition, there was a significant negative correlation between intakes of mono unsaturated fatty acids (MUFA) with EDSS in all participants.
Correlation between saturated fatty acids (SFAs) with EDSS and fatigue scale was significantly positive in all participants. Although correlation between total dietary fats with EDSS and fatigue scale in all participants and subgroups were positive, but not significant.
Age, gender and blood pressure were not confounder variables. In addition, the researchers adjusted energy intakes in subgroups.
Researchers concluded that the study demonstrated that there is a positive significant correlation between intakes of SFAs with EDSS and fatigue scale in all participants. In addition dietary intakes PUFAs and MUFAs can decrease EDSS in all patients with MS.
However, they did feel that further studies with larger sample sizes and other populations are needed to prove this correlation.[/QUOTE]
[URL="http://www.ms-uk.org/fats-and-oils-impa ... ts-ectrims"][U]Fats and oils[/U][/URL] impact disability in MS patients #ECTRIMS
[QUOTE]A study has shown a significant correlation between the intake of saturated fatty acids and disability and fatigue in MS patients.
The study consisted of 126 patients diagnosed with MS (84 RRMS, 21 PPMS and 21 SPMS) who were recruited with MRI assessment of the brain and spinal cord from an MS clinic in Kashani Hospital of Isfahan University of Medical Sciences, in Iran.
All participants were assessed using a 168-item semi-quantitive food frequency questionnaire to assess dietary intakes of fatty acids, a medical history questionnaire, the expanded disability status scale (EDSS) and a fatigue questionnaire.
The average EDSS and fatigue scale in the SPMS and PPMS groups was significantly higher than the RRMS group. There was a significant correlation between intakes of polyunsaturated fatty acids (PUFAs) including linolenic acid and linoleic acid with EDSS in all participants. In addition, there was a significant negative correlation between intakes of mono unsaturated fatty acids (MUFA) with EDSS in all participants.
Correlation between saturated fatty acids (SFAs) with EDSS and fatigue scale was significantly positive in all participants. Although correlation between total dietary fats with EDSS and fatigue scale in all participants and subgroups were positive, but not significant.
Age, gender and blood pressure were not confounder variables. In addition, the researchers adjusted energy intakes in subgroups.
Researchers concluded that the study demonstrated that there is a positive significant correlation between intakes of SFAs with EDSS and fatigue scale in all participants. In addition dietary intakes PUFAs and MUFAs can decrease EDSS in all patients with MS.
However, they did feel that further studies with larger sample sizes and other populations are needed to prove this correlation.[/QUOTE]
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RoOsJe *59
Beste Marsei,
Ik ben heel erg geïnteresseerd in jouw postings en doe echt mijn stinkende best om het te lezen,
maar de lengte en de taal maken dat erg moeilijk :huilen:
Dat vind ik hartstikke jammer.
Van jouw laatste bericht dringt het gewoon niet tot mij door of de vetten ervoor zorgen dat mijn ms wordt geremd of juist “aangespoord”. :???:
En of het verzadigde of onverzadigde vetten zijn.
Ik begrijp dat het veel gevraagd is maar zou jij of iemand anders een korte samenvatting bij de geplaatste berichten kunnen geven?
Alvast heel erg bedankt.
Ik ben heel erg geïnteresseerd in jouw postings en doe echt mijn stinkende best om het te lezen,
maar de lengte en de taal maken dat erg moeilijk :huilen:
Dat vind ik hartstikke jammer.
Van jouw laatste bericht dringt het gewoon niet tot mij door of de vetten ervoor zorgen dat mijn ms wordt geremd of juist “aangespoord”. :???:
En of het verzadigde of onverzadigde vetten zijn.
Ik begrijp dat het veel gevraagd is maar zou jij of iemand anders een korte samenvatting bij de geplaatste berichten kunnen geven?
Alvast heel erg bedankt.
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MarcC
Het onderzoek toont aan dat meervoudig onverzadigde vetten ervoor kunnen zorgen dat je EDSS verbetert/daalt.
Deze zitten in onder andere zonnebloemolie, maïsolie, sojaolie, notenolie, druivenpitolie, vette vis.
Verzadigde vetten (boter, kaas, vlees, gebak) kan voor eens stijging van je EDSS zorgen.
groetjes, Marc
Deze zitten in onder andere zonnebloemolie, maïsolie, sojaolie, notenolie, druivenpitolie, vette vis.
Verzadigde vetten (boter, kaas, vlees, gebak) kan voor eens stijging van je EDSS zorgen.
groetjes, Marc
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Jenniez
Vitamine en supplementen na prednison kuur
Vitamine en supplementen na prednison kuur
Hoi allemaal,
Ik heb op dit moment een prednison kuur via infuus, graag zou ik extra supplementen en vitamines willen slikken om me weerstand weer op pijl te krijgen.
Iemand tip voor mij?
Groetjes,
Jennie
Hoi allemaal,
Ik heb op dit moment een prednison kuur via infuus, graag zou ik extra supplementen en vitamines willen slikken om me weerstand weer op pijl te krijgen.
Iemand tip voor mij?
Groetjes,
Jennie
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RoOsJe *59
[QUOTE=MarcC;1095932]Het onderzoek toont aan dat meervoudig onverzadigde vetten ervoor kunnen zorgen dat je EDSS verbetert/daalt.
Deze zitten in onder andere zonnebloemolie, maïsolie, sojaolie, notenolie, druivenpitolie, vette vis.
Verzadigde vetten (boter, kaas, vlees, gebak) kan voor eens stijging van je EDSS zorgen.
groetjes, Marc[/QUOTE]
Dankjewel Marc. Zo wordt het wel iets duidelijker.
Geldt dit ook als ik al in de SP-fase zit? M.a.w. heeft het dan ook zin?
Deze zitten in onder andere zonnebloemolie, maïsolie, sojaolie, notenolie, druivenpitolie, vette vis.
Verzadigde vetten (boter, kaas, vlees, gebak) kan voor eens stijging van je EDSS zorgen.
groetjes, Marc[/QUOTE]
Dankjewel Marc. Zo wordt het wel iets duidelijker.
Geldt dit ook als ik al in de SP-fase zit? M.a.w. heeft het dan ook zin?
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MarcC